Combining Two-Directional Synthesis and Tandem Reactions, Part 8: A Novel Condensation/Michael Addition/Cycloaddition/Fragmentation/Lactamisation Cascade

Sinclair, Alex, Arini, Louise, Rejzek, Martin , Szeto, Peter and Stockman, Robert (2006) Combining Two-Directional Synthesis and Tandem Reactions, Part 8: A Novel Condensation/Michael Addition/Cycloaddition/Fragmentation/Lactamisation Cascade. Synlett, 2006(14), pp. 2321-2324. ISSN (print) 0936-5214

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Abstract

A tandem oxime formation/Michael addition/1,4-prototopic shift/[3+2]-cycloaddition of an acyclic symmetrical precursor results in a tricyclic isooxazolidine which then undergoes a further fragmentation/lactamisation cascade to generate a non-symmetrical tricyclic a-ketolactam as a single diastereomer

Item Type: Article
Research Area: Chemistry
Faculty, School or Research Centre: Faculty of Science (until 2011)
Faculty of Science, Engineering and Computing > School of Pharmacy and Chemistry
Depositing User: Alex Sinclair
Date Deposited: 07 Feb 2012 11:23
Last Modified: 16 Jul 2012 21:49
URI: http://eprints.kingston.ac.uk/id/eprint/17357

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