Rosas-Magallanes, Vania, Stadthagen-Gomez, Gustavo, Rauzier, Jean, Barreiro, Luis B., Tailleux, Ludovic, Boudou, Frederic, Griffin, Ruth, Nigou, Jerome, Jackson, Mary, Gicquel, Brigitte and Neyrolles, Olivier (2007) Signature-tagged transposon mutagenesis identifies novel ' Mycobacterium tuberculosis ' genes involved in the parasitism of human macrophages. Infection And Immunity, 75(1), pp. 504-507. ISSN (print) 0019-9567

Abstract

Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.

Downloads Metadata

Full text available as:

Item Type:	Article
Additional Information:	This work was supported by Institut Pasteur and the European Community [contracts QLK2-CT-2001-02018 and QLK2-CT-2000- 01761].
Research Area:	Research Areas > Biological sciences
Faculty, School or Research Centre:	Faculty of Science (until 2011)
Related URLs:	PubMed
Date Deposited:	07 Apr 2017 09:22
Last Modified:	06 Oct 2020 14:56
URI:	https://eprints.kingston.ac.uk/id/eprint/33824

Actions (Repository Editors)

Item Control Page