Karlyshev, A.V., Thacker, G., Jones, M.A., Clements, M.O. and Wren, B.W. (2014) 'Campylobacter jejuni' gene cj0511 encodes a serine peptidase essential for colonisation. FEBS Open Bio, 4, pp. 468-472. ISSN (online) 2211-5463
Abstract
According to MEROPS peptidase database, Campylobacter species encode 64 predicted peptidases. However, proteolytic properties of only a few of these proteins have been confirmed experimentally. In this study we identified and characterised a Campylobacter jejuni gene cj0511 encoding a novel peptidase. The proteolytic activity associated with this enzyme was demonstrated in cell lysates. Moreover, enzymatic studies conducted with a purified protein confirmed a prediction of it being a serine peptidase. Furthermore, cj0511 mutant was found to be severely attenuated in chicken colonisation model, suggesting a role of the Cj0511 protein in infection.
Actions (Repository Editors)
 |
Item Control Page |