Grootveld, M, Claxson, A, Naughton, Declan and Blake, D (1991) A biochemical investigation of auranofin nephrotoxicity by high field proton nuclear magnetic resonance spectroscopy. In: Satellite Symp Of The 9th International Congress Of Pharmacology : Drugs In Inflammation; 28-29 Jun, 1990, Noordwijk, Netherlands. (Agents and Actions Supplements, no. 32)Full text not available from this archive.
High-field proton NMR spectroscopic analysis of urine and plasma has been employed to study the biochemical effects and nephrotoxic action of an intramuscular dose of auranofin in rats. Auranofin induced a characteristic profile of proximal tubular damage as evidenced by aminoaciduria, lactic aciduria and increased urinary acetate concentrations. In addition, ethanol was detectable in both urine and plasma obtained from auranofin-treated rats. Auranofin-mediated elevations in the plasma and urine concentrations of 3-D-hydroxybutyrate indicated an increased utilisation of fats for fuel in rats treated with this novel therapeutic agent.
|Item Type:||Conference or Workshop Item (Paper)|
|Event Title:||Satellite Symp Of The 9th International Congress Of Pharmacology : Drugs In Inflammation|
|Research Area:||Allied health professions and studies|
|Faculty, School or Research Centre:||Faculty of Science (until 2011) > School of Life Sciences
Faculty of Science (until 2011)
|Depositing User:||Declan Naughton|
|Date Deposited:||29 Feb 2012 11:26|
|Last Modified:||29 Feb 2012 11:26|
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