Grootveld, M, Claxson, A, Naughton, Declan and Blake, D (1991) A biochemical investigation of auranofin nephrotoxicity by high field proton nuclear magnetic resonance spectroscopy. In: Satellite Symp Of The 9th International Congress Of Pharmacology : Drugs In Inflammation; 28-29 Jun, 1990, Noordwijk, Netherlands. (Agents and Actions Supplements, no. 32)

Abstract

High-field proton NMR spectroscopic analysis of urine and plasma has been employed to study the biochemical effects and nephrotoxic action of an intramuscular dose of auranofin in rats. Auranofin induced a characteristic profile of proximal tubular damage as evidenced by aminoaciduria, lactic aciduria and increased urinary acetate concentrations. In addition, ethanol was detectable in both urine and plasma obtained from auranofin-treated rats. Auranofin-mediated elevations in the plasma and urine concentrations of 3-D-hydroxybutyrate indicated an increased utilisation of fats for fuel in rats treated with this novel therapeutic agent.

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