A Two-Directional Synthesis of (+/-)-Perhydrohistrionicotoxin

Stockman, Robert, Sinclair, Alex, Arini, Louise, Szeto, Peter and Hughes, David (2004) A Two-Directional Synthesis of (+/-)-Perhydrohistrionicotoxin. The Journal of Organic Chemistry, 69(5), pp. 1598-1602. ISSN (print) 0022-3263

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Abstract

An entirely two-directional synthesis of (+/-)-perhydrohistrionicotoxin is presented, utilizing a tandem oxime formation/Michael addition/[3 + 2] cycloaddition as the key step. This approach also constitutes formal syntheses of (+/-)-histrionicotoxin and (+/-)-histrionicotoxin 235A.

Item Type: Article
Research Area: Chemistry
Faculty, School or Research Centre: Faculty of Science (until 2011)
Faculty of Science, Engineering and Computing > School of Pharmacy and Chemistry
Depositing User: Alex Sinclair
Date Deposited: 07 Feb 2012 11:01
Last Modified: 07 Feb 2012 11:01
URI: http://eprints.kingston.ac.uk/id/eprint/17359

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