Article

Sim, Edith and Ryan, Ali (2017) Drug metabolism and antibiotic resistance in micro-organisms. British Journal of Pharmacology, 174(14), pp. 2159-2160. ISSN (print) 0007-1188

Ryan, Ali, Polycarpou, Elena, Lack, Nathan A., Evangelopoulos, Dimitrios, Sieg, Christian, Halman, Alice, Bhakta, Sanjib, Eleftheriadou, Olga, McHugh, Timothy D., Keany, Sebastian, Lowe, Edward D., Ballet, Romain, Abuhammad, Areej, Jacobs Jr., William R., Ciulli, Alessio and Sim, Edith (2017) Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach. British Journal of Pharmacology, 174(14), pp. 2209-2224. ISSN (print) 0007-1188

Crescente, Vincenzo, Holland, Sinead, Kashyap, Sapna, Polycarpou, Elena, Sim, Edith and Ryan, Ali (2016) Identification of novel members of the bacterial azoreductase family in 'Pseudomonas aeruginosa'. Biochemical Journal, 473(5), pp. 549-558. ISSN (print) 0264-6021

Laurieri, Nicola, Kawamura, Akane, Westwood, Isaac M., Varney, Amy, Morris, Elizabeth, Russell, Angela J., Stanley, Lesley A. and Sim, Edith (2014) Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding. BMC Pharmacology & Toxicology, 15(68), ISSN (online) 2050-6511

Abuhammad, Areej, Fullam, Elizabeth, Bhakta, Sanjib, RUSSELL, Angela J., Morris, Garrett M., Finn, Paul W. and Sim, Edith (2014) Exploration of Piperidinols as Potential Antitubercular Agents. Molecules, 19(10), pp. 16274-16290. ISSN (online) 1420-3049

Ryan, Ali, Kaplan, Elise, Nebel, Jean-Christophe, Polycarpou, Elena, Crescente, Vincenzo, Lowe, Edward, Preston, Gail M and Sim, Edith (2014) Identification of NAD(P)H Quinone Oxidoreductase Activity in Azoreductases from P. aeruginosa: Azoreductases and NAD(P)H Quinone Oxidoreductases Belong to the Same FMN-Dependent Superfamily of Enzymes. PloS ONE, 9(6), e98551. ISSN (online) 1932-6203

Egleton, James E., Thinnes, Cyrille C., Seden, Peter T., Laurieri, Nicola, Lee, Siu Po, Hadavizadeh, Kate S., Measures, Angelina R., Jones, Alan M., Thompson, Sam, Varney, Amy, Wynne, Graham M., Ryan, Ali, Sim, Edith and Russell, Angela J. (2014) Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine [Nu]-acetyltransferase 1. Bioorganic & Medicinal Chemistry, 22(11), pp. 3030-3054. ISSN (print) 0968-0896

Sim, E., Abuhammad, A. and Ryan, A. (2014) Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery. British Journal of Pharmacology, 171(11), pp. 2705-2725. ISSN (print) 0007-1188

Laurieri, Nicola, Dairou, Julien, Egleton, James E, Stanley, Lesley A, Russell, Angela J., Dupret, Jean-Marie, Sim, Edith and Rodrigues-Lima, Fernando (2014) From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase : impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2. PloS ONE, 9(5), ISSN (online) 1932-6203

Sim, Edith (2014) Arylamine n-acetyltransferases structure in drug metabolism and drug discovery. Drug Metabolism Reviews, 45, p. 8. ISSN (print) 0360-2532

Boukouvala, Sotiria, Tsirka, Theodora, Sabbagh, Audrey, Sim, Edith, Crouau-Roy, Brigitte and Fakis, Giannoulis (2014) Recombinant arylamine n-acetyltransferases of non-human primates as models for in vitro evaluation of pharmaceutical compounds. Drug Metabolism Reviews, 45, pp. 66-67. ISSN (print) 0360-2532

Ryan, Ali, Keany, Sebastian, Eleftheriadou, Olga, Ballet, Romain, Cheng, Hung-Yuan and Sim, Edith (2014) Research Letter: Mechanism-based inhibition of HsaD: a C-C bond hydrolase essential for survival of M. tuberculosis in macrophage. FEMS Microbiology Letters, 350(1), pp. 42-47. ISSN (print) 0378-1097

Boukouvala, Sotiria, Davies, Britton, Kotseli, Barbara, Kontomina, Evanthia, Garefalaki, Vasiliki, Fakis, Giannoulis, Sim, Edith, Marialigeti, Karoly and Glenn, Anthony E. (2014) Xenobiotic detoxification from an environmental perspective: the roles of microbial arylamine n-acetyltransferases. Drug Metabolism Reviews - Official Journal of the International Society for the Study of Xenobiotics (ISSX), 45, pp. 121-122. ISSN (print) 0360-2532

Abuhammad, Areej, Lowe, Edward D., McDonough, Michael A., Stewart, Patrick D. Shaw, Kolek, Stefan A., Sim, Edith and Garman, Elspeth F. (2013) Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity. Acta Crystallographica Section D-Biological Crystallography, 69(8), pp. 1433-1446. ISSN (print) 0907-4449

Sim, Edith, Fakis, Giannoulis, Laurieri, Nicola and Boukouvala, Sotiria (2012) Arylamine N-acetyltransferases - from drug metabolism and pharmacogenetics to identification of novel targets for pharmacological intervention. Advances in Pharmacology, 63, pp. 169-205. ISSN (print) 1054-3589

Abuhammad, A, Lack, N, Schweichler, J, Staunton, D, Sim, RB and Sim, E (2011) Improvement of the expression and purification of Mycobacterium tuberculosis arylamine N-acetyltransferase (TBNAT) a potential target for novel anti-tubercular agents. Protein Expression and Purification, 80(2), pp. 246-252. ISSN (print) 1046-5928

Ryan, Ali, Kaplan, Elise, Laurieri, Nicola, Lowe, Edward and Sim, Edith (2011) Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. Scientific Reports, 1, ISSN (online) 2045-2322

Fullam, Elizabeth, Abuhammad, Areej, Wilson, David L., Anderton, Matthew C., Davies, Steve G., Russell, Angela J. and Sim, Edith (2011) Analysis of beta-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase. Bioorganic & Medicinal Chemistry Letters, 21(4), pp. 1185-1190. ISSN (print) 0960-894X

Westwood, I. M., Kawamura, A, Russell, A. J., Sandy, J, Davies, S. G. and Sim, E (2011) Novel Small-Molecule Inhibitors of Arylamine N-Acetyltransferases: Drug Discovery by High Throughput Screening. Combinatorial Chemistry & High Throughput Screening, 14(2), pp. 117-124. ISSN (print) 1386-2073

Abuhammad, Areej M., Lowe, Edward D., Fullam, Elizabeth, Noble, Martin, Schweichler, Judith, Garman, Elspeth F. and Sim, Edith (2010) Structural Studies on the Mycobacterial Arylamine N-Acetyltransferases. Drug Metabolism Reviews - Official Journal of the International Society for the Study of Xenobiotics (ISSX), 42(Suppl. 1), pp. 111-112.

Ryan, Ali, Laurieri, Nicola, Westwood, Isaac, Wang, Chan-Ju, Lowe, Edward and Sim, Edith (2010) A novel mechanism for azoreduction. Journal of Molecular Biology, 400(1), pp. 24-37. ISSN (print) 0022-2836

Laurieri, Nicola, Crawford, Matthew H. J., Kawamura, Akane, Westwood, Isaac M., Robinson, James, Fletcher, Ai M., Davies, Stephen G., Sim, Edith and Russell, Angela J. (2010) Small Molecule Colorimetric Probes for Specific Detection of Human Arylamine N-Acetyltransferase 1, a Potential Breast Cancer Biomarker. Journal of the American Chemical Society, 132(10), pp. 3238-3239. ISSN (print) 0002-7863

Lack, Nathan A., Yam, Katherine C., Lowe, Edward D., Horsman, Geoff P., Owen, Robin L., Sim, Edith and Eltis, Lindsay D. (2010) Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism. Journal of Biological Chemistry, 285(1), pp. 434-443. ISSN (print) 0021-9258

Lack, Nathan A., Kawamura, Akane, Fullam, Elizabeth, Laurieri, Nicola, Beard, Stacey, Russell, Angela J., Evangelopoulos, Dimitrios, Westwood, Isaac and Sim, Edith (2009) Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis. Biochemical Journal, 418(2), pp. 369-378. ISSN (print) 0264-6021

Sim, Edith, Sandy, James, Evangelopoulos, Dimitrios, Fullam, Elizabeth, Bhakta, Sanjib, Westwood, Isaac, Krylova, Anna, Lack, Nathan and Noble, Martin (2008) Arylamine N-acetyltransferases in mycobacteria. Current Drug Metabolism, 9(6), pp. 510-519. ISSN (print) 1389-2002

Simard, Emilie, Naud, Judith, Michaud, Josee, Leblond, Francois A., Bonnardeaux, Alain, Guillemette, Chantal, Sim, Edith and Pichette, Vincent (2008) Downregulation of hepatic acetylation of drugs in chronic renal failure. Journal of the American Society of Nephrology, 19(7), pp. 1352-1359. ISSN (print) 1046-6673

Sim, E. (2008) Abstract: Pharmacogenomics: from drug metabolism to disease susceptibility and beyond. Febs Journal, 275(Suppl. 1), p. 12. ISSN (print) 1742-464X

Hein, David W., Boukouvala, Sotiria, Grant, Denis M., Minchin, Rodney F. and Sim, Edith (2008) Changes in consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics And Genomics, 18(4), pp. 367-368. ISSN (print) 1744-6872

Kawamura, Akane, Westwood, Isaac, Wakefield, Larissa, Long, Hilary, Zhang, Naixia, Walters, Kylie, Redfield, Christina and Sim, Edith (2008) Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1. Biochemical Pharmacology, 75(7), pp. 1550-1560. ISSN (print) 0006-2952

Wakefield, Larissa, Robinson, James, Long, Hilary, Ibbitt, J. Claire, Cooke, Susanna, Hurst, Helen C. and Sim, Edith (2008) Arylamine N-acetyltransferase I expression in breast cancer cell lines: A potential marker in estrogen receptor-positive tumors. Genes, chromasomes & cancer, 47(2), pp. 118-126. ISSN (print) 1045-2257

Wakefield, Larissa, Cornish, Valerie, Long, Hilary, Kawamura, Akane, Zhang, Xiaoyan, Hein, David W. and Sim, Edith (2008) Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system. Biomarkers, 13(1), pp. 106-118. ISSN (print) 1354-750X

Fullam, Elizabeth, Westwood, Isaac M., Anderton, Matthew C., Lowe, Edward D., Sim, Edith and Noble, Martin E. M. (2008) Divergence of cofactor recognition across evolution: Coenzyme a binding in a prokaryotic arylamine N-acetyltransferase. Journal of Molecular Biology, 375(1), pp. 178-191. ISSN (online) 0022-2836

Lack, Nathan, Lowe, Edward D., Liu, Jie, Eltis, Lindsay D., Noble, Martin E. M., Sim, Edith and Westwood, Isaac M. (2008) Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis. Acta Crystallographica Section F-Structural Biology And Crystallization Communications, 64(Part 1), pp. 2-7. ISSN (online) 1744-3091

Wakefield, Larissa, Cornish, Valerie, Long, Hilary, Griffiths, William J. and Sim, Edith (2007) Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism. Biochemical and Biophysical Research Communications, 364(3), pp. 556-560. ISSN (print) 0006-291X

Wang, Chan-Ju, Hagemeier, Christoph, Rahman, Nawreen, Lowe, Edward, Noble, Martin, Coughtrie, Michael, Sim, Edith and Westwood, Isaac (2007) Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa. Journal of Molecular Biology, 373(5), pp. 1213-1228. ISSN (online) 0022-2836

Carroll, Maria V., Krarup, Anders, Sim, Edith and Sim, Robert B. (2007) Complement activation with Mycobacterium bovis BCG. Molecular Immunology, 44(16), p. 2834. ISSN (print) 0161-5890

Smellie, Iain A., Bhakta, Sanjib, Sim, Edith and Fairbanks, Antony J. (2007) Synthesis of putative chain terminators of mycobacterial arabinan biosynthesis. Organic & Biomolecular Chemistry, 5(14), pp. 2257-2266. ISSN (print) 1477-0520

Madikane, Vukani Eliya, Bhakta, Sanjib, Russell, Angela J., Campbell, William E., Claridge, Timothy D. W., Elisha, B. Gay, Davies, Stephen G., Smith, Peter and Sim, Edith (2007) Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris. Bioorganic & Medicinal Chemistry, 15(10), pp. 3579-3586. ISSN (print) 0968-0896

Sim, Edith, Westwood, Isaac and Fullam, Elizabeth (2007) Arylamine N-acetyltransferases. Expert Opinion On Drug Metabolism & Toxicology, 3(2), pp. 169-184. ISSN (print) 1742-5255

Wakefield, Larissa, Long, Hilary, Lack, Nathan and Sim, Edith (2007) Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene. Mammalian Genome, 18(4), pp. 270-276. ISSN (print) 0938-8990

Van der Geize, R., Yam, K., Heuser, T., Wilbrink, M.H., Hara, H., Anderton, M.C., Sim, E., Dijkhuizen, L., Davies, J.E., Mohn, W.W. and Eltis, L.D. (2007) A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 104(6), pp. 1947-1952. ISSN (online) 1091-6490

Loehle, Jennifer A., Cornish, Valerie, Wakefield, Larissa, Doll, Mark A., Neale, Jason R., Zang, Yu, Sim, Edith and Hein, David W. (2006) N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice. Journal of Pharmacology and Experimental Therapeutics, 319(2), pp. 724-728. ISSN (print) 0022-3565

Wakefield, Larissa, Kawamura, Akane, Long, Hilary and Sim, Edith (2006) Abstract: Neuroendocrine expression of mouse arylamine N-acetyltransferase 2. Genetical Research, 88(1), p. 74. ISSN (print) 0016-6723

Westwood, I. M., Kawamura, A., Fullam, E., Russell, A. J., Davies, S. G. and Sim, E. (2006) Structure and mechanism of arylamine N-acetyltransferases. Current Topics In Medicinal Chemistry, 6(15), pp. 1641-1654. ISSN (print) 1568-0266

Rodrigues-Lima, F., Dairou, J., Diaz, C.L., Rubio, M.C., Sim, E., Spaink, H.P. and Dupret, J.M. (2006) Cloning, functional expression and characterization of Mesorhizobium loti arylamine N-acetyltransferases: rhizobial symbiosis supplies leguminous plants with the xenobiotic N-acetylation pathway. Molecular Microbiology, 60(2), pp. 505-512. ISSN (print) 0950-382X

Dairou, Julien, Flatters, Delphine, Chaffotte, Alain F., Pluvinage, Benjamin, Sim, Edith, Dupret, Jean-Marie and Rodrigues-Lima, Fernando (2006) Insight into the structure of Mesorhizobium loti arylamine N-acetyltransferase 2 (MLNAT2): A biochemical and computational study. FEBS Letters, 580(7), pp. 1780-1788. ISSN (print) 0014-5793

Salvador-Morales, Carolina, Flahaut, Emmanuel, Sim, Edith, Sloan, Jeremy, Green, Malcolm L.H. and Sim, Robert B. (2006) Complement activation and protein adsorption by carbon nanotubes. Molecular Immunology, 43(3), pp. 193-201. ISSN (print) 0161-5890

Anderton, Matthew C., Bhakta, Sanjib, Besra, Gurdyal S., Jeavons, Peter, Eltis, Lindsay D. and Sim, Edith (2006) Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG. Molecular Microbiology, 59(1), pp. 181-192. ISSN (print) 0950-382X

Sholto-Douglas-Vernon, Carolyn, Sandy, James, Victor, Thomas C., Sim, Edith and van Helden, Paul D. (2005) Mutational and expression analysis of tbnat and its response to isoniazid. Journal of Medical Microbiology, 54(12), pp. 1189-1197. ISSN (print) 0022-2615

Sandy, James, Mushtaq, Adeel, Holton, Simon J., Schartau, Pamela, Noble, Martin E.M. and Sim, Edith (2005) Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines. Biochemical Journal, 390(Part 1), pp. 115-123. ISSN (print) 0264-6021

Wakefield, Larissa, Cornish, Valerie, Broackes-Carter, Fiona and Sim, Edith (2005) Arylamine N-acetyltransferase 2 expression in the developing heart. Journal of Histochemistry and Cytochemistry, 53(5), pp. 583-592. ISSN (print) 0022-1554

Boukouvala, Sotiria and Sim, Edith (2005) Structural analysis of the genes for human arylamine N-acetyltransferases and characterisation of alternative transcripts. Basic & Clinical Pharmacology & Toxicology, 96(5), pp. 343-351. ISSN (print) 1742-7835

Sandy, James, Holton, Simon, Fullam, Elizabeth, Sim, Edith and Noble, Martin (2005) Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis. Protein Science, 14(3), pp. 775-782. ISSN (print) 0961-8368

Wang, Haiqing, Vath, Gregory M., Kawamura, Akane, Bates, Caleb A., Sim, Edith, Hanna, Patrick E. and Wagner, Carston R. (2005) Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1. The Protein Journal, 24(2), pp. 65-77. ISSN (print) 1572-3887

Kawamura, Akane, Graham, James, Mushtaq, Adeel, Tsiftsoglou, Stefanos A., Vath, Gregory M., Hanna, Patrick E., Wagner, Carson R. and Sim, Edith (2005) Eukaryotic arylamine N-acetyltransferase investigation of substrate specificity by high-throughput screening. Biochemical Pharmacology, 69(2), pp. 347-359. ISSN (print) 0006-2952

Holton, Simon J., Dairou, Julian, Sandy, James, Rodrigues-Lima, Fernando, Dupret, Jean-Marie, Noble, Martin E.M. and Sim, Edith (2005) Structure of Mesorhizobium loti arylamine N-acetyltransferase 1. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 61(Part 1), pp. 14-16. ISSN (online) 1744-3091

Westwood, Isaac M., Holton, Simon J., Rodrigues-Lima, Fernando, Dupret, Jean-Marie, Bhakta, Sanjib, Noble, Martin E.M. and Sim, Edith (2005) Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase. Biochemical Journal, 385(Part 2), pp. 605-612. ISSN (print) 0264-6021

Wakefield, Larissa, Cornish, Valerie, Long, Hilary, Broackes-Carter, Fiona, Mo, Mimi, Bhattacharya, Shoumo and Sim, Edith (2004) Abstract: Expression of arylamine N-acetyl transferase in the developing heart. Genetical Research, 84(2), pp. 123-124. ISSN (print) 0016-6723

Smits, Kim M., Benhamou, Simone, Garte, Seymour, Weijenberg, Matty P., Alamanos, Yannis, Ambrosone, Christine, Autrup, Herman, Autrup, Judith L., Baranova, Helena, Bathum, Lisa, Boffetta, Paolo, Bouchardy, C., Brockmoller, Jurgen, Butkiewicz, Dorota, Cascorbi, Ingolf, Clapper, Margie L., Coutelle, Christiane, Daly, Ann K., Muzi, Giacomo, Dolzan, Vita, Duzhak, Tatyana G., Farker, Katrin, Golka, Klaus, Haugen, Aage, Hein, David W., Hildesheim, Allan, Hirvonen, Ari, Hsieh, Ling L., Ingelman-Sundberg, Magnus, Kalina, Ivan, Kang, Daehee, Katoh, Takahiko, Kihara, Masahiro, Ono-Kihara, Masako, Kim, Heon, Kiyohara, Chikako, Kremers, Pierre, Lazarus, Philip, Le Marchand, Loic, Lechner, Maria C., London, Stephanie, Manni, Johannes J., Maugard, Christine M., Morgan, Gareth J., Morita, Shunji, Nazar-Stewart, Valle, Kristensen, Vessela Nedelcheva, Oda, Yoshio, Parl, Fritz F., Peters, Wilbert H.M., Rannug, Agneta, Rebbeck, Timothy, Pinto, Luis F.Rigiero, Risch, Angela, Romkes, Marjorie, Salagovic, Jan, Schoket, Bernadette, Seidegard, Janeric, Shields, Peter G., Sim, Edith, Sinnett, Daniel, Strange, Richard C., Stucker, Isabelle, Sugimura, Haruhiko, To-Figueras, Jordi, Vineis, Paloa, Yu, Mimi C., Zheng, Wwe, Pedotti, Paola and Taioli, Emmanuela (2004) Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. International Journal of Cancer, 110(2), pp. 266-270. ISSN (print) 0020-7136

Bhakta, Sanjib, Besra, Gurdyal S., Upton, Anna M., Parish, Tanya, Sholto-Douglas-Vernon, Carolyn, Gibson, Kevin J. C., Knutton, Stuart, Gordon, Siamon, daSilva, Rosangela P., Anderton, Matthew C. and Sim, Edith (2004) Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target. The Journal of Experimental Medicine (JEM), 199(9), pp. 1191-1199. ISSN (print) 0022-1007

Boukouvala, Sotiria, Price, Naomi, Plant, Kathryn E. and Sim, Edith (2003) Structure and transcriptional regulation of the Nat2 gene encoding for the drug-metabolizing enzyme arylamine N-acetyltransferase type 2 in mice. Biochemical Journal, 375(Part 3), pp. 593-602. ISSN (print) 0264-6021

Adam, Paul J., Berry, Joanne, Loader, Julie A., Tyson, Kerry L., Craggs, Graham, Smith, Paul, De Belin, Jackie, Steers, Graham, Pezzella, Francesco, Sachsenmeir, Kris F, Stamps, Alasdair C., Herath, Athula, Sim, Edith, O'Hare, Michael J., Harris, Adrian L. and Terrett, Jonathan A. (2003) Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro. Molecular Cancer Research, 1(11), pp. 826-835. ISSN (print) 1541-7786

Brooke, Edward W., Davies, Stephen G., Mulvaney, Andrew W., Okada, Minoru, Pompeo, Frédérique, Sim, Edith, Vickers, Richard J. and Westwood, Isaac M. (2003) Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs). Bioorganic & Medicinal Chemistry Letters, 13(15), pp. 2527-2530. ISSN (print) 0960-894X

Sim, E., Pinter, K., Mushtaq, A., Upton, A., Sandy, J., Bhakta, S. and Noble, M. (2003) Arylamine N-acetyltransferases: a pharmacogenomic approach to drug metabolism and endogenous function. Biochemical Society Transactions, 31(3), pp. 615-619. ISSN (print) 0300-5127

Rodrigues-Lima, Fernando, Cooper, Raquel N., Goudeau, Bertrand, Atmane, Noureddine, Chamagne, Anne-Marie, Butler-Browne, Gillian, Sim, Edith, Vicart, Patrick and Dupret, Jean-Marie (2003) Skeletal muscles express the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase. Journal of Histochemistry & Cytochemistry, 51(6), pp. 789-796. ISSN (print) 0022-1554

Brooke, Edward W., Davies, Stephen G, Mulvaney, Andrew W, Pompeo, Frederique, Sim, Edith and Vickers, Richard J. (2003) An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases. Bioorganic & Medicinal Chemistry, 11(7), pp. 1227-1234. ISSN (print) 0968-0896

Delgoda, Rupika, Lian, Lu-Yun, Sandy, James and Sim, Edith (2003) NMR investigation of the catalytic mechanism of arylamine N-acetyltransferase from Salmonella typhimurium. BBA - Biochimica et Biophysica Acta General Subjects, 1620(1-3), pp. 8-14.

Kawamura, Akane, Sandy, James, Upton, Anna, Noble, Martin and Sim, Edith (2003) Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase. Protein Expression and Purification, 27(1), pp. 75-84. ISSN (print) 1046-5928

Cornish, V.A., Pinter, K., Boukouvala, S., Johnson, N., Labrousse, C., Payton, M., Priddle, H., Smith, A.J.H. and Sim, E (2003) Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene. The Pharmacogenomics Journal, 3(3), pp. 169-177. ISSN (print) 1470-269X

Sim, Edith (2002) Editorial: Pharmacogenomics of arylamine N-acetyltransferases - from drug metabolism to drug discovery. Pharmaocogenomics, 3(6), pp. 729-731. ISSN (print) 1462-2416

Boukouvala, Sotiria, Price, Naomi and Sim, Edith (2002) Identification and functional characterization of novel polymorphisms associated with the genes for arylamine N-acetyltransferases in mice. Pharmacogenetics, 12(5), pp. 385-394. ISSN (print) 0960-314X

Sandy, James, Mushtaq, Adeel, Kawamura, Akane, Sinclair, John, Sim, Edith and Noble, Martin (2002) The structure of arylamine N-acetyltransferase from mycobacterium smegmatis - An enzyme which inactivates the anti-tubercular drug, Isoniazid. Journal of Molecular Biology, 318(4), pp. 1071-1083. ISSN (print) 0022-2836

Mushtaq, Adeel, Payton, Mark and Sim, Edith (2002) The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity. Journal of Biological Chemistry, 277(14), pp. 12175-12181. ISSN (print) 0021-9258

Pompeo, Frédérique, Mushtaq, Adeel and Sim, Edith (2002) Expression and purification of the rifamycin amide synthase, RifF, an enzyme homologous to the prokaryotic arylamine N-acetyltransferases. Protein Expression and Purification, 24(1), pp. 138-151. ISSN (print) 1046-5928

Pompeo, Frédérique, Brooke, Edward, Kawamura, Akane, Mushtaq, Adeel and Sim, Edith (2002) The pharmacogenetics of NAT: structural aspects. Pharmacogenomics, 3(1), pp. 19-30. ISSN (print) 1470-269X

Vineis, Paolo, Marinelli, Daniela, Autrup, Herman, Brockmoller, Jurgen, Cascorbi, Ingolf, Daly, Ann K., Golka, Klaus, Okkels, Henry, Risch, Angela, Rothman, Nathalien, Sim, Edith and Taioli, Emanuela (2001) Current smoking, occupation, N-acetyltransferase-2 and bladder cancer: A pooled analysis of genotype-based studies. Cancer Epidemiology Biomarkers & Prevention (CEBP), 10(12), pp. 1249-1252. ISSN (print) 1055-9965

Payton, Mark, Gifford, Claire, Schartau, Pamela, Hagemeier, Chris, Mushtaq, Adeel, Lucas, Stuart, Pinter, Katalin and Sim, Edith (2001) Evidence towards the role of arylamine N-acetyltransferase in Mycobacterium smegmatis and development of a specific antiserum against the homologous enzyme of Mycobacterium tuberculosis. Microbiology, 147(Part 12), pp. 3295-3302. ISSN (print) 1350-0872

Upton, A.M., Mushtaq, A., Victor, T.C., Sampson, S.L., Sandy, J., Smith, D.M., van Helden, P.V. and Sim, E. (2001) Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism. Molecular Microbiology, 42(2), pp. 309-317. ISSN (print) 0950-382X

Williams, J.Andrew, Stone, Elaine M., Fakis, Giannoulis, Johnson, Nichola, Cordell, Jacky A., Meinl, Walter, Glatt, Hansruedi, Sim, Edith and Phillips, David H. (2001) N-acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast. Pharmacogenetics, 11(5), pp. 373-388. ISSN (print) 0960-314X

Upton, Anna, Johnson, Nicola, Sandy, James and Sim, Edith (2001) Arylamine N-acetyltransferases - of mice, men and microorganisms. Trends in Pharmacological Sciences, 22(3), pp. 140-146. ISSN (print) 0165-6147

Upton, Anna, Smelt, Valerie, Mushtaq, Adeel, Aplin, Robin, Johnson, Nicola, Mardon, Helen and Sim, Edith (2000) Placental arylamine N-acetyltransferase type 1: potential contributory source of urinary folate catabolite p-acetamidobenzoylglutamate during pregnancy. BBA - Biochimica et Biophysica Acta, 1524(2-3), pp. 143-148. ISSN (print) 0304-4165

Pirmohamed, M., Alfirevic, A., Vilar, J., Stalford, A., Wilkins, E.G.L., Sim, E. and Park, B.K. (2000) Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity. Pharmacogenetics, 10(8), pp. 705-713. ISSN (print) 0960-314X

Sim, Edith, Payton, Mark, Noble, Martin and Minchin, Rodney (2000) An update on genetic, structural and functional studies of arylamine N-acetyltransferases in eucaryotes and procaryotes. Human Molecular Genetics, 9(16), pp. 2435-2441. ISSN (print) 0964-6906

Fakis, G., Boukouvala, S., Buckle, V., Payton, M., Denning, C. and Sim, E. (2000) Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2. Cytogenetics and Cell Genetics, 90(1-2), pp. 134-138. ISSN (print) 1424-8581

Sinclair, John C., Sandy, James, Delgoda, Rupika, Sim, Edith and Noble, Martin E.M. (2000) Letter: Structure of arylamine N-acetyltransferase reveals a catalytic triad. Nature Structural and Molecular Biology, 7(7), pp. 560-564. ISSN (print) 1545-9993

Hein, David W, Grant, Denis M. and Sim, Edith (2000) Update on consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics, 10(4), pp. 291-292. ISSN (print) 0960-314X

Smelt, V.A., Upton, A., Adjaye, J., Payton, M.A., Boukouvala, S., Johnson, N., Mardon, H.J. and Sim, E. (2000) Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos. Human Molecular Genetics, 9(7), pp. 1101-1107. ISSN (print) 0964-6906

Stevens, Gregory J., Payton, Mark, Sim, Edith and McQueen, Charlene A. (1999) N-acetylation of the heterocyclic amine batracylin by human liver. Drug Metabolism and Disposition, 27(9), pp. 966-971. ISSN (print) 0090-9556

Mongey, A.B., Sim, E., Risch, A. and Hess, E. (1999) Acetylation status is associated with serological changes but not clinically significant disease in patients receiving procainamide. Journal of Rheumatology, 26(8), pp. 1721-1726. ISSN (print) 0315-162X

Payton, Mark, Auty, Roy, Delgoda, Rupika, Everett, Martin and Sim, Edith (1999) Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: Increased expression results in isoniazid resistance. Journal of bacteriology, 181(4), pp. 1343-1347. ISSN (print) 0021-9193

Thygesen, Peter, Risch, Angela, Stacey, Mike, Fakis, Giannoulis, Takle, Lindsay, Knowles, Margaret and Sim, Edith (1999) Genes for human arylamine N-acetyltransferases in relation to loss of the short arm of chromosome 8 in bladder cancer. Pharmacogenetics, 9(1), pp. 1-8. ISSN (print) 0960-314X

Stanley, L. A., Copp, A. J., Pope, J, Rolls, S, Smelt, V, Perry, V. H. and Sim, Edith (1998) Immunochemical detection of arylamine N-acetyltransferase during mouse embryonic development and in adult mouse brain. Teratology, 58(5), pp. 174-182. ISSN (online) 1542-0760

Smelt, Valerie A., Mardon, Helen J. and Sim, Edith (1998) Placental expression of arylamine N-acetyltransferases: Evidence for linkage disequilibrium between NAT1*10 and NAT2*4 alleles of the two human arylamine N-acetyltransferase loci NAT1 and NAT2. Pharmacology & Toxicology, 83(4), pp. 149-157. ISSN (print) 0901-9928

Watters, A.D., Stacey, M.W., Going, J.J., Grigor, K.M., Cooke, T.G., Sim, E. and Barlett, J.M.S. (1998) Abstract: Genetic alterations of N-acetyl transferase in transitional cell carcinoma of the bladder. British Journal of Cancer, 78(2), p. 154. ISSN (print) 0007-0920

Lanzrein, Anne-Sophie, Jobst, Kim A., Thiel, Steffen, Jensenius, Jens Christian, Sim, Robert B., Perry, V.Hugh and Sim, Edith (1998) Mannan-binding lectin in human serum, cerebrospinal fluid and brain tissue and its role in Alzheimer's disease. NeuroReport, 9(7), pp. 1491-1495. ISSN (print) 0959-4965

Sinclair, John C., Delgoda, Rupika, Noble, Martin E.M., Jarmin, Sarah, Goh, Ngee K. and Sim, Edith (1998) Purification, characterization, and crystallization of an N-hydroxyarylamine O-acetyltransferase from Salmonella typhimurium. Protein Expression and Purification, 12(3), pp. 371-380. ISSN (print) 1046-5928

Hickman, D., Pope, J., Patil, S.D., Fakis, G., Smelt, V., Stanley, L.A., Payton, M., Unadkat, J.D. and Sim, E. (1998) Expression of arylamine N-acetyltransferase in human intestine. Gut, 42(3), pp. 402-409. ISSN (print) 0017-5749

Payton, Mark A and Sim, Edith (1998) Genotyping human arylamine N-acetyltransferase type 1 (NAT1) - The identification of two novel allelic variants. Biochemical Pharmacology, 55(3), pp. 361-366. ISSN (print) 0006-2952

Smelt, V.A., Mardon, H.J., Redman, C.W.G. and Sim, E. (1997) Acetylation of arylamines by the placenta. European Journal of Drug Metabolism and Pharmacokinetics, 22(4), pp. 403-408. ISSN (print) 0378-7966

Stanley, LA, Mills, IG and Sim, Edith (1997) Localization of polymorphic N-acetyltransferase (NAT2) in tissues of inbred mice. Pharmacogenetics, 7(2), pp. 121-130. ISSN (print) 0960-314X

Matas, N, Thygesen, P, Stacey, M, Risch, A and Sim, Edith (1997) Mapping AAC1, AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours. Cytogenetics and Cell Genetics, 77(3-4), pp. 290-295. ISSN (print) 0301-0171

Sinclair, John and Sim, Edith (1997) A fragment consisting of the first 204 amino-terminal amino acids of human arylamine N-acetyltransferase one (NAT1) and the first transacetylation step of catalysis. Biochemical Pharmacology, 53(1), pp. 11-16. ISSN (print) 0006-2952

Stanley, Lesley A., Coroneos, Erifili, Cuff, Rebecca, Hickman, Dean, Ward, Alison and Sim, Edith (1996) Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder. Journal of Histochemisty and Cytochemistry, 44(9), pp. 1059-1067. ISSN (print) 0022-1554

Stacey, Michael, Thygesen, Peter, Stanley, Lesley, Matas, Nada, Risch, Angela and Sim, Edith (1996) Arylamine N-acetyltransferase as a potential biomarker in bladder cancer: Fluorescent in situ hybridization and immunohistochemistry studies. Biomarkers, 1(1), pp. 55-61. ISSN (print) 1354-750X

Sim, Edith (1991) Drug-Induced immune complex disease. Biochemical Society Transactions, 19(1), pp. 164-170. ISSN (print) 0300-5127

Kelly, S. L. and Sim, E. (1991) Expression Of Normal-Acetyl transferase in a human monocytic cell-line, U937. Human & Experimental Toxicology, 10(1), pp. 33-38. ISSN (print) 0960-3271

Watson, Anne P., Wang, Patrick D. and Sim, Edith (1990) Arylamine N-Acetyltransferase from fast (C57BL6) and slow (A/J) N-Acetylating strains of mice. Biochemical Pharmacology, 39(4), pp. 647-654. ISSN (print) 0006-2952

MitchellL, J A, Sim, R B and Sim, Edith (1989) CR-1 polymorphism in hydralazine-induced systemic lupus-erythematosus - DNA restriction fragment length polymorphism. Clinical And Experimental Immunology, 78(3), pp. 354-358. ISSN (print) 0009-9104

Sim, Edith, Dodds, Alister W and Goldin, Amanda (1989) Inhibition of the covalent binding reaction of complement component C-4 by penicillamine, an anti-rheumatic agent. Biochemical Journal, 259(2), pp. 415-419. ISSN (print) 0264-6021

Sim, E. (1989) Drug-induced immune-complex disease. Complement And Inflamatio, 6(2), pp. 119-126. ISSN (print) 1012-8204

Sim, Edith (1988) Letter: Immunogenetics and rheumatoid-arthritis. Immunology Today, 9(5), p. 132. ISSN (print) 0167-5699

Sim, Edith, Stanley, Lesley, Gill, Edward W. and Jones, Alison (1988) Metabolites of procainamide and practolol inhibit complement component-C3 and component-C4. Biochemical Journal, 251(2), pp. 323-326. ISSN (print) 0264-6021

Sim, Edith, Wood, M, Parker, K. E. and Jones, A (1988) Interation of nucleophilic compounds with complement component-C4. Comparative Immunology Microbiology And Infectious Diseases, 11(3-4), pp. 163-170. ISSN (print) 0147-9571

Christie, Angela, Burgess, Anne P. and Sim, Edith (1987) N-Acetyltransferase activity in cultured-cells. Biochemical Society Transactions, 15(3), p. 449. ISSN (print) 0300-5127

Mitchell, J. A., Batchelor, J. R., Chapel, H., Spiers, C. N. and Sim, E. (1987) Erythrocyte complement receptor type-1 (CR-1) expression and circulating immune-complex (CIC) levels in hydralazine-induced SLE. Clinical And Experimental Immunology, 68(2), pp. 446-456. ISSN (print) 0009-9104

Dyer, Simon H., Sim, Edith and Cook, William F. (1986) Kinetics of a Soluble L-Leucine-Beta-Naphthylamide-Hydrolyzing Activity from Rat-Brain. Biochemical Society Transactions, 14(6), pp. 1276-1277. ISSN (print) 0300-5127

Sim, Edith and Cross, Susan J. (1986) Phenotyping of human complement component-C4, a class-III HLA antigen. Biochemical Journal, 239(3), pp. 763-767. ISSN (print) 0264-6021

Sim, Edith., Dodds, A.W., Wood, M. and Sim, R.B. (1986) Rapid purification of C-4 from indvidual donors. Biochemical Society Transactions, 14(1), pp. 77-78. ISSN (print) 0300-5127

Sim, Edith, Jones, Alison and Stanley, Lesley (1985) Acetohydroxamate, a Urease Inhibitor, Inhibits the Covalent Binding Reaction of Complement Proteins C3 and C4. Acta Pharmacologica et Toxicologica, 57(4), pp. 304-306. ISSN (online) 0001-6683

Micklem, Kingsley, Sim, Edith and SIM, Robert B. (1985) The generation of active fragments of complement receptor type 2 by trypsin digestion. FEBS Letters, 189(2), pp. 195-201. ISSN (online) 0014-5793

Sim, Edith and Law, Sai-Kit A. (1985) Hydralazine binds covalently to complement component-C4: Different reactivity of C4A AND C4B Gene-Products. FEBS letters, 184(2), pp. 323-327. ISSN (print) 0014-5793

Sim, Edith (1985) More drugs interact with the complement system. Trends in Pharmacological Sciences, 6(5), pp. 197-198. ISSN (online) 0165-6147

Sim, Edith (1984) Synthesis of tritium labelled phosphonium choline. Journal of Labelled Compounds & Radiopharmaceuticals, 21(6), pp. 587-592. ISSN (online) 1099-1344

Conference or Workshop Item

Mo, M.M., Cornish, V., Donnellan, R., Taylor, B., Khodabukus, N., Labrousse, C., Pinter, K.L., Boukouvala, S. and Sim, E. (2002) Arylamine N-acetyltransferase and folate catabolism. In: 13th Genetics Society's Mammalian Genetics and Development Workshop; 27-28 Nov 2002, London, U.K.. ISSN (print) 0016-6723