The synthesis and biological evaluation of a range of novel functionalised benzopyrans as potential potassium channel activators

Tyrrell, Elizabeth, Tesfa, Kibur Hunie, Greenwood, Iain and Mann, Alistair (2008) The synthesis and biological evaluation of a range of novel functionalised benzopyrans as potential potassium channel activators. Bioorganic & Medicinal Chemistry Letters, 18(3), pp. 1237-1240. ISSN (print) 0960-894X

Official URL: http://dx.doi.org/10.1016/j.bmcl.2007.11.135

Abstract

A range of novel benzopyrans have been synthesised and biologically evaluated for K(ATP) channel activity employing cromakalim 1 as a benchmark K(ATP) channel opener. Although the compounds that were evaluated demonstrated a reduced ability to relax phenylephrine stimulated rat thoracic tissue, we provide evidence that benzopyrans 7a-h may be operating via an alternative mechanism than ATP-sensitive K(+) channel activity.

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