Factors associated with retinal vessel traits in the Canadian longitudinal study on aging

O'Neil, Alexis, Welikala, Roshan A., Barman, Sarah, Owen, Christopher G., Rudnicka, Alicja R., Rakesh, Mohan, Roy-Gagnon, Marie-Hélène, Maberley, David and Freeman, Ellen E. (2025) Factors associated with retinal vessel traits in the Canadian longitudinal study on aging. Investigative Ophthalmology & Visual Science, 66(3), p. 13. ISSN (print) 0146-0404

Abstract

This study aims to determine the factors cross-sectionally and longitudinally associated with retinal vessel diameter, total area, and tortuosity in the Canadian Longitudinal Study on Aging (CLSA). Current smoking was strongly associated with wider arteriolar and venular diameters and their widening over 3 years (P < 0.05). Current smoking was also associated with a larger arteriolar and venular area and a 3-year increase in venular area (P < 0.05). Obesity was positively associated with venular diameter, total venular area, 3-year change in total venular area, and venular tortuosity (P < 0.05). Diastolic blood pressure was negatively associated with both arteriolar and venular diameter, area, and tortuosity, both cross-sectionally and longitudinally (P < 0.05). Diabetes was associated with wider arteriolar diameters cross-sectionally, and type 1 diabetes was associated with 3-year widening of arteriolar diameters (P < 0.05).

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