Comparison of profile of non motor symptoms in Japanese patients with PD with European patients and healthy controls. Extension of the NMSQuest study

Tsuboi, Y., Yamada, T., Chaudhuri, R. K., Martinez-Martin, P., Schapira, A. H., PDNMG International Parkinson's Disease Non-Motor Group, ... and Naidu, Y. (2006) Comparison of profile of non motor symptoms in Japanese patients with PD with European patients and healthy controls. Extension of the NMSQuest study. In: 10th International Congress of Parkinson's Disease and Movement Disorders; 27 Oct - 2 Nov 2006, Kyoto, Japan. (Unpublished)

Abstract

Objective: To evaluate the prevalence of non-motor symptoms (NMS) inJapanese PD patients by using NMS Questionnaire, and compare theprofile of NMS with PD with European patients and healthy controls.Background: Early identification and evaluation of NMS of PD patientsare necessary so that it has been known that NMS in PD patients is closelyrelated with quality of life. In late years a European PD non-motor groupdeveloped a new NMS questionnaire (NMSQuest) and confirmed theutility.Methods: NMSQuest is NMS screening questionnaire containing 30items of non-motor questionnaires. This instrument does not provide anoverall score of disability and is not a graded or rating instrument. Japanesetranslation of NMSQuest (NMSQuest-J) was used in this study. Consec-utive Japanese PD patients were invited to fill out the NMSQuest-J.Original European data consists of 123 PD patients and 96 controls.Results: Fifty-three PD patients completed the NMSQuest-J (mean age:66.1±11.2 years, mean disease duration: 6.9±4.7 years, mean Hoehn-Yahr stage: 2.7). There are no differences in these demographic data withEuropean PD patients. The most commonly reported non-motor symptomswere constipation (78.4%), nocturia (75%), memory problem (64.7%). andlacking of concentration (82.4%). Constipation, swallow problem, apathy,loss of concentration, fall and diplopia were reported more frequently inJapanese PD patients than European PD patients.Conclusions: NMS was highly and significantly more prevalent in Jap-anese and European PD patients than controls. In several items such as constipation, swallow problem, apathy, loss of concentration, fall anddiplopia, Japanese patients reported more frequently than European pa-tients. The differences in NMS prevalence among different races might becaused by cultural difference. NMS in PD patients is the crucial problemoften underdiagnosed.

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