Pereira, Susana, Patel, Ryan, Zaima, Ahmed, Tvarozkova, Katarina, Chisholm, Philippa, Kappelou, Olga, Evanson, Jane, Chandraharan, Edwin, Wertheim, David and Shah, Divyen K. (2022) Physiological CTG categorization in types of hypoxia compared with MRI and neurodevelopmental outcome in infants with HIE. The Journal of Maternal-Fetal & Neonatal Medicine, 35(25), pp. 9675-9683. ISSN (print) 1476-7058
Abstract
This study examines whether a relationship exists between the types of hypoxia as identified on the cardiotocograph using novel physiology-based CTG classification and patterns of injury on neonatal cerebral MRI and later neurodevelopmental outcomes. A retrospective study of term-born infants admitted to four neonatal units with HIE as part of a brain injury biomarkers study between January 2014 and December 2015. Intrapartum CTG traces were analyzed by two obstetricians trained in physiological CTG classification, blind to neonatal outcomes. Neonatal cerebral MR images were assessed independently by a neuroradiologist and an expert neonatologist. CTG traces were classified into types of hypoxia and allocated to groups; (1) chronic hypoxia or antepartum injury; (2) gradually evolving or subacute hypoxia; and (3) acute hypoxia. Using this novel physiology-based CTG classification, we demonstrate an association between types of hypoxia observed on the CTG and MRI patterns of hypoxic brain injury. Infants with CTG trace suggestive of chronic hypoxia or other antenatal injuries were overrepresented in this cohort and were also more likely to have a poor neurodevelopmental outcome.
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