Caprifico, Anna E., Foot, Peter J.S., Polycarpou, Elena and Calabrese, Gianpiero (2021) Overcoming the protein corona in chitosan-based nanoparticles. Drug Discovery Today, 26(8), pp. 1825-1840. ISSN (print) 1359-6446

Abstract

Numerous properties of chitosan have led to its extensive use in the formulation of nanomaterials for drug delivery. However, the cationic surface of chitosan-based nanoparticles adsorbs proteins upon exposure to biological fluids, forming a phenomenon known as ‘protein corona’. This causes several effects such as decreased bioavailability and limited in vivo clinical applications of chitosan nanoparticles. Understanding and overcoming the effects of protein adsorption on chitosan nanoparticles is key for drug delivery purposes. This review focuses on the strategies implemented to increase the stability of chitosan nanoparticles in the systemic circulation by averting the formation of protein corona and the limitations of PEGylation

Downloads Metadata

Full text available as:

Official URL:	https://doi.org/10.1016/j.drudis.2021.04.014
Item Type:	Article
Research Area:	Research Areas > Biological sciences Research Areas > Chemistry Research Areas > Pharmacy
Faculty, School or Research Centre:	Faculty of Science, Engineering and Computing Faculty of Science, Engineering and Computing > School of Life Sciences, Pharmacy and Chemistry
Date Deposited:	06 May 2021 14:41
Last Modified:	21 Apr 2022 02:05
DOI:	https://doi.org/10.1016/j.drudis.2021.04.014
URI:	https://eprints.kingston.ac.uk/id/eprint/48971

Actions (Repository Editors)

Item Control Page