Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands

Coban, Tomris, Robertson, Cameron, Schwikkard, Sianne, Singer, Richard and LeGresley, Adam (2021) Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands. RSC Medicinal Chemistry, ISSN (online) 2632-8682 (Epub Ahead of Print)

Abstract

The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.

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