Coban, Tomris, Robertson, Cameron, Schwikkard, Sianne, Singer, Richard and LeGresley, Adam (2021) Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands. RSC Medicinal Chemistry, 5, pp. 751-757. ISSN (online) 2632-8682

Abstract

The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.

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Official URL:	https://doi.org/10.1039/D0MD00428F
Item Type:	Article
Research Area:	Research Areas > Chemistry
Faculty, School or Research Centre:	Faculty of Science, Engineering and Computing Faculty of Science, Engineering and Computing > School of Life Sciences, Pharmacy and Chemistry
Related URLs:	Europe PMC
SWORD Depositor:	Mr Jisc Router
Date Deposited:	06 Apr 2021 10:37
Last Modified:	27 Jul 2021 12:34
DOI:	https://doi.org/10.1039/D0MD00428F
URI:	https://eprints.kingston.ac.uk/id/eprint/48774

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