Fattahi, Sadegh, Amjadi-Moheb, Fatemeh, Tabaripour, Reza, Ashrafi, Gholam Hossein and Akhavan-Niaki, Haleh (2020) PI3K/AKT/mTOR signaling in gastric cancer : epigenetics and beyond. Life sciences, 262, p. 118513. ISSN (print) 0024-3205

Abstract

PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved in normal cellular processes. Its aberrant activation modulates autophagy, epithelial-mesenchymal transition, apoptosis, chemoresistance, and metastasis in many human cancers. Emerging evidence demonstrates that some infections as well as epigenetic regulatory mechanisms can control PI3K/AKT/mTOR signaling pathway. In this review, we focused on the role of this pathway in gastric cancer development, prognosis, and metastasis, with an emphasis on epigenetic alterations including DNA methylation, histone modifications, and post-transcriptional modulations through non-coding RNAs fluctuations as well as H. pylori and Epstein-Barr virus infections. Finally, we reviewed different molecular targets and therapeutic agents in clinical trials as a potential strategy for gastric cancer treatment through the PI3K/AKT/mTOR pathway. [Abstract copyright: Copyright © 2020 Elsevier Inc. All rights reserved.]

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Official URL:	https://doi.org/10.1016/j.lfs.2020.118513
Item Type:	Article
Uncontrolled Keywords:	Chemoresistance, Epigenetic modulation, Gastric cancer, Non-coding RNAs, PI3K/AKT/mTOR pathway, Targeted therapy
Research Area:	Research Areas > Pre-clinical and human biological sciences
Faculty, School or Research Centre:	Faculty of Science, Engineering and Computing Faculty of Science, Engineering and Computing > School of Life Sciences, Pharmacy and Chemistry
SWORD Depositor:	Mr Jisc Router
Date Deposited:	19 Nov 2020 11:16
Last Modified:	01 Oct 2021 02:05
DOI:	https://doi.org/10.1016/j.lfs.2020.118513
URI:	https://eprints.kingston.ac.uk/id/eprint/47265

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