Caprifico, Anna E., Polycarpou, Elena, Foot, Peter J. S. and Calabrese, Gianpiero (2021) Biomedical and pharmacological uses of fluorescein isothiocyanate chitosan-based nanocarriers. Macromolecular Bioscience, 21(1), p. 2000312. ISSN (print) 1616-5187
Abstract
Chitosan-based nanocarriers (ChNCs) are considered suitable drug carriers due to their ability to encapsulate a variety of drugs and cross biological barriers to deliver the cargo to their target site. Fluorescein isothiocyanate-labeled chitosan-based NCs (FITC@ChNCs) are used extensively in biomedical and pharmacological applications. The main advantage of using FITC@ChNCs consists of the ability to track their fate both intra and extracellularly. This journey is strictly dependent on the physico-chemical properties of the carrier and the cell types under investigation. Other applications make use of fluorescent ChNCs in cell labeling for the detection of disorders in vivo and controlling of living cells in situ. This review describes the use of FITC@ChNCs in the various applications with a focus on understanding their usefulness in labeled drug-delivery systems
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