Sher, Gulab, Salman, Nadia Aziz, Kulinski, Michal, Fadel, Rayyan Abdulaziz, Gupta, Vinod Kumar, Anand, Ambika, Gehani, Salahddin, Abayazeed, Sheraz, Al-Yahri, Omer, Shahid, Fakhar, Alshaibani, Salman, Hassan, Sara, Chawdhery, M. Zafar, Davies, Giles, Dermime, Said, Uddin, Shahab, Ashrafi, G. Hossein and Junejo, Kulsoom (2020) Prevalence and type distribution of high-risk Human Papillomavirus (HPV) in breast cancer : a Qatar based study. Cancers, 12(6), p. 1528. ISSN (online) 2072-6694
Abstract
Human papillomavirus (HPV) has been implicated in the etiology of a variety of human cancers. Studies investigating the presence of high-risk (HR) HPV in breast tissue have generated considerable controversy over its role as a potential risk factor for breast cancer (BC). This is the first investigation reporting the prevalence and type distribution of high-risk HPV infection in breast tissue in the population of Qatar. A prospective comparison blind research study herein reconnoitered the presence of twelve HR-HPV types’ DNA using multiplex PCR by screening a total of 150 fresh breast tissue specimens. Data obtained shows that HR-HPV types were found in 10% of subjects with breast cancer; of which the presence of HPV was confirmed in 4/33 (12.12%) of invasive carcinomas. These findings, the first reported from the population of Qatar, suggest that the selective presence of HPV in breast tissue is likely to be a related factor in the progression of certain cases of breast cancer.
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