Mapping of the diabetes polygene Idd3 on mouse Chromosome 3 using novel congenic strains

Lord, C. J., Bohlander, S. K., Hopes, E. A., Montague, C. T., Hill, N. J., Prins, J.-B., Peterson, L. B., Wicker, L. S., Todd, J. A. and Denny, P. (1995) Mapping of the diabetes polygene Idd3 on mouse Chromosome 3 using novel congenic strains. Mammalian Genome, 6(9), pp. 563-570. ISSN (print) 0938-8990

Official URL: https://doi.org/10.1007/BF00352359

Abstract

Development of novel congenic mouse strains has allowed us to better define the location of the diabetogenic locus, Idd3, on Chromosome (Chr) 3. Congenic strains were identified by use of published and newly developed microsatellite markers, their genomes fingerprinted by a rapid, fluorescence-based approach, and their susceptibility to type 1 diabetes evaluated. The maximum interval containing Idd3 is now approximately 4 cM.

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