Jhunjhunwalla, Kamal, Singh, Rabindra Kumar, Barton, Stephen, Barker, James and Busquets, Rosa (2015) Interpretations from the calculation of Equivalent Alkane Carbon Number (EACN) for a range of synthetic aroma molecules. In: HPLC 2015 : 42nd International Conference on High Performance Liquid Phase Separations and Related Techniques; 21 - 25 Jun 2015, Geneva, Switzerland. (Unpublished)

Abstract

Methods Solutions of 0.5g of each chemical with 0.5g of reference, methyl decanoate were made. These were then run on a 7890A Agilent Gas Chromatograph. The samples were run at the following temperature program: initial temperature at 70°C, temperature ramp of 2°C until 270°C at the end of 100 minutes. Each sample was run in triplicate for statistical confidence. Results The calculated Equivalent Alkane Carbon Numbers range across a wide spectrum. However, instances of similarities in the 149 EACNs of molecules within the same functional group have been observed. As an example, the calculated EACNs ester molecules – manzanate, mahagonate, bulgarate and cyclogalbanate fall in the range of 0.93 to 1.04. This proximity to 1 is also alluded to the fact that the reference molecules is a methyl ester. EACNs of molecules with carbonyl functional groups such as Claritone, Florazone, Melozone and Orivone are within 1.06 and 1.14. Among polycyclic musks, Cellestolide, Cervolide and Habanolide have EACNs within 1.08 and 1.11 while Romandolide and Helveltolide are outliers.

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