Khelwatty, Said A., Essapen, Sharadah, Seddon, Alan M., Fan, Zhen and Modjtahedi, Helmout (2015) Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers. British Journal of Cancer, 113(7), pp. 1010-1019. ISSN (print) 0007-0920

Abstract

Our results provide a novel mechanistic insight into the development of acquired resistance to EGFR antibody-based therapy in colorectal cancer cells and justify further investigations on the therapeutic benefits of pan-HER family inhibitors in the treatment of colorectal cancer patients once acquired resistance to EGFR antibody-based therapy is developed.

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Official URL:	http://dx.doi.org/10.1038/bjc.2015.319
Item Type:	Article
Additional Information:	This work was supported by a grant from Better Research Into Gastrointestinal Cancer Health and Treatment (BRIGHT), UK.
Research Area:	Research Areas > Cancer studies
Faculty, School or Research Centre:	Faculty of Science, Engineering and Computing (until 2017) Faculty of Science, Engineering and Computing (until 2017) > School of Life Sciences
Related URLs:	PubMed
Date Deposited:	21 Sep 2015 19:30
Last Modified:	10 Nov 2020 08:15
DOI:	https://doi.org/10.1038/bjc.2015.319
URI:	https://eprints.kingston.ac.uk/id/eprint/32508

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