The suprachoroidal pathway: a new drug delivery route to the back of the eye

Rai, Uma Do J. P., Young, Simon A., Thrimawithana, Thilini R., Abdelkader, Hamdy, Alani, Adam W. G., Pierscionek, Barbara and Alany, Raid G. (2015) The suprachoroidal pathway: a new drug delivery route to the back of the eye. Drug Discovery Today, 20(4), pp. 491-495. ISSN (print) 1359-6446

Official URL: http://dx.doi.org/10.1016/j.drudis.2014.10.010

Abstract

The development of safe and convenient drug delivery strategies for treatment of posterior segment eye diseases is challenging. Although intravitreal injection has wide acceptance amongst clinicians, its use is associated with serious side-effects. Recently, the suprachoroidal space (SCS) has attracted the attention of ophthalmologists and pharmaceutical formulators as a potential site for drug administration and delivery to the posterior segment of the eye. This review highlights the major constraints of drug delivery to the posterior eye segment, key anatomical and physiological features of the SCS and drug delivery applications of this route with emphasis on microneedles along with future perspectives.

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