Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens

Abdelkader, H., Alany, R.G. and Pierscionek, B. (2015) Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens. Journal of Pharmacy and Pharmacology, 67(4), pp. 537-550. ISSN (print) 0022-3573

Official URL: http://dx.doi.org/10.1111/jphp.12355

Abstract

This review discusses the anatomy and physiology of the lens and the changes that are understood to occur with ageing and cataract formation to identify potential areas for effective therapeutic intervention. Experimental techniques and agents used to induce cataract in animal models, the advantages and disadvantages of potential pharmacological treatments specific barriers to delivery of exogenous antioxidants to the lens and the prospects for future research are discussed.

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