Bahrami, Mehdi, Hoshino, Masato, Pierscionek, Barbara, Yagi, Naoto, Regini, Justyn and Uesugi, Kentaro (2014) Optical properties of the lens: An explanation for the zones of discontinuity. Experimental Eye Research, 124, pp. 93-99. ISSN (print) 0014-4835
Abstract
The structural basis of zones of discontinuity in the living human eye lens has not been elucidated, and there is no conclusive explanation for what relevance they may have to the structure and function of the lens. Newly developed synchrotron radiation based X-ray Talbot interferometry has enabled the detection of subtle fluctuations in the human eye lens which, when used in mathematical modelling to simulate reflected and scattered light, can recreate the image of the lens seen in the living human eye. The results of this study show that the zones of discontinuity may be caused by subtle fluctuations in the refractive index gradient as well as from random scattering in the central regions. As the refractive index contours are created by cell layers with progressively varying protein concentrations, the zones are linked to growth and will contain information about ageing and development. The index gradient is important for image quality and fluctuations in this gradient may add to quality optimisation and serve as models for designs of new generation implant lenses.
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