A biochemical investigation of auranofin nephrotoxicity by high field proton nuclear magnetic resonance spectroscopy

Grootveld, Martin, Claxson, Andrew, Naughton, Declan and Blake, David (1991) A biochemical investigation of auranofin nephrotoxicity by high field proton nuclear magnetic resonance spectroscopy. Agents and Actions Supplements, 32, pp. 59-63. ISSN (print) 0379-0363

Official URL: http://www.ncbi.nlm.nih.gov/pubmed/2069098

Abstract

High-field proton NMR spectroscopic analysis of urine and plasma has been employed to study the biochemical effects and nephrotoxic action of an intramuscular dose of auranofin in rats. Auranofin induced a characteristic profile of proximal tubular damage as evidenced by aminoaciduria, lactic aciduria and increased urinary acetate concentrations. In addition, ethanol was detectable in both urine and plasma obtained from auranofin-treated rats. Auranofin-mediated elevations in the plasma and urine concentrations of 3-D-hydroxybutyrate indicated an increased utilisation of fats for fuel in rats treated with this novel therapeutic agent.

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