Structure activity relationship study of known inhibitors of the enzyme 5-[aplha]-reductase (5AR)

Ahmed, Sabbir and Denison, Sophie (1998) Structure activity relationship study of known inhibitors of the enzyme 5-[aplha]-reductase (5AR). Bioorganic & Medicinal Chemistry Letters, 8(5), pp. 409-414. ISSN (print) 0960-894X

Abstract

Preliminary results of a modelling study of both steroidal and non-steroidal inhibitors of 5 alpha-reductase (5AR) are described in order to elucidate the essential structural requirements needed for the design of novel non-steroidal inhibitors. The study suggests that: (i) there is a requirement for groups to mimic the C(3) = O of the steroid substrate A-ring; (ii) the area of the active site about the C(17)-OH position of the substrate does not appear to possess hydrogen bonding groups and is unrestricted.

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