Fractal dimension and wavelet decomposition for robust microarray data clustering

Istepanian, Robert S.H., Sungoor, Ala and Nebel, Jean-Christophe (2008) Fractal dimension and wavelet decomposition for robust microarray data clustering. In: 30th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society; 20 - 24 Aug 2008, Vancouver, Canada. ISSN (print) 1557-170X

Official URL: http://dx.doi.org/10.1109/IEMBS.2008.4650112

Abstract

Microarrays are now established technologies which are considered as key to gene expression analysis. Their study is usually achieved by using clustering techniques. Genomic signal processing is a new area of research that combines genomics with digital signal processing methodologies. In this paper, we present a comparative analysis of two genomic signal processing methods for robust microarray data clustering. Techniques based on Fractal Dimension and Discrete Wavelet Decomposition with Vector Quantization are validated for standard data sets. Comparative analysis of the results indicates that these methods provide improved clustering accuracy compared to some conventional clustering techniques. Moreover, these classifiers don't require any prior training procedures.

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