Items where Kingston Author is "Owen, Caroline"

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Number of items: 36.

Waheed, Abdul, Barker, James, Barton, Stephen J, Owen, Caroline P, Ahmed, Sabbir and Carew, Mark A (2012) A novel steroidal saponin glycoside from Fagonia indica induces cell-selective apoptosis or necrosis in cancer cells. European Journal of Pharmaceutical Sciences, 47(2), pp. 464-473. ISSN (print) 0928-0987

AHMED, SABBIR, Shahid, Imran, Bhatti, Kishore, Lee, Wai-Yee and Owen, Caroline (2009) Synthesis and Biochemical Evaluation of a Range of 2-, 3-and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17 alpha-hydroxylase/17,20-Lyase (P450(17 alpha)). Letters in Drug Design and Discovery, 6(7), pp. 524-530. ISSN (print) 1570-1808

Shah, Kruti, Olusanjo, Moniola S., Cartledge, Tim, Owen, Caroline P. and Ahmed, Sabbir (2009) Synthesis and biochemical evaluation of a series of methanesulfonate derivatives of 4-hydroxyphenyl ketone as probes of the active site of type 3 OF 17[beta]-hydroxysteroid dehydrogenase family of enzymes. Letters in Drug Design and Discovery, 6(7), pp. 518-523. ISSN (print) 1570-1808

Ahmed, S., Owen, C. P., Waheed, A., Nisa, S. [Collaborator], Bibi, Y. [Collaborator] and Chaudhary, M. Fayyaz [Collaborator] (2009) Biochemical evaluation of extracts from Caralluma tuberculata against hormone-dependent breast cancer cells. In: British Pharmaceutical Conference (BPC); 6-9 Sep 2009, Manchester, U.K.. (Journal of Pharmacy and Pharmacology) ISSN (print) 0022-3573

Owen, C.P. (2009) 17alpha-hydroxylase/17,20-lyase (p450(17alpha)) inhibitors in the treatment of prostate cancer: a review. Anti-Cancer Agents in Medicinal Chemistry, 9(6), pp. 613-626. ISSN (print) 1871-5206

Lota, Rupinder K., Olusanjo, Moniola S., Dhanani, Sachin, Owen, Caroline P. and Ahmed, Sabbir (2008) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-hydroxyphenyl ketones as potent and specific inhibitors of the type 3 of 17[beta]-hydroxysteroid dehydrogenase (17[beta]-HSD3). The Journal of Steroid Biochemistry and Molecular Biology, 111(1-2), pp. 128-137. ISSN (print) 0960-0760

Owen, Caroline P., Shahid, Imran, Olusanjo, Moniola S, Patel, Chirag H., Dhanani, Sachin and Ahmed, Sabbir (2008) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17[alpha]-hydroxylase/17,20-lyase (P450(17[alpha])). The Journal of Steroid Biochemistry and Molecular Biology, 111(1-2), pp. 117-127. ISSN (print) 0960-0760

Shahid, Imran, Patel, Chirag H., Dhanani, Sachin, Owen, Caroline P. and Ahmed, Sabbir (2008) Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17[alpha]-Hydroxylase/17,20-Lyase (P450[sub]17[alpha]). The Journal of Steroid Biochemistry and Molecular Biology, 110(1-2), pp. 18-29. ISSN (print) 0960-0760

Adat, Shaheen, Owen, Caroline P. and Ahmed, Sabbir (2007) Inhibition of aromatase (AR) by benzyl azole-based compounds. Letters in Drug Design and Discovery, 4(8), pp. 545-549. ISSN (print) 1570-1808

Owen, Caroline, Dhanani, Sachin, Patel, Chirag and Ahmed, Sabbir (2007) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-substituted phenyl alkyl triazole-based compounds as potential inhibitors of 17 alpha-hydroxylase/17,20-lyase (P450(17 alpha)). Letters in Drug Design and Discovery, 4(7), pp. 479-483. ISSN (print) 1570-1808

Owen, Caroline, Patel, Mijal, Patel, Chirag, Cartledge, Tim and Ahmed, Sabbir (2007) Synthesis and in vitro biochemical evaluation of a series of compounds as potential inhibitors of estrone sulfatase (ES) and the role of pK(a) in both the synthesis and the inhibitory activity of the potential inhibitors. Letters in Drug Design and Discovery, 4(6), pp. 394-398. ISSN (print) 1570-1808

Owen, Caroline, Patel, Chirag, Cartledge, Tim and Ahmed, Sabbir (2007) Synthesis and in vitro biochemical evaluation of a series of cycloalkyl esters of 4-sulfamoylated benzoic acid as inhibitors of estrone sulfatase (ES). Letters in Drug Design and Discovery, 4(6), pp. 399-403. ISSN (print) 1570-1808

Waheed, A., Aidoo-Gyamfi, K., Owen, C. and Ahmed, S. (2007) The synthesis of a series of amides based upon 4-hydroxybenzoic acid in the development of potential inhibitors of the enzymes oestrone sulphatase. In: The British Pharmaceutical Conference; 10 - 12 Sept 2007, Manchester, U.K..

Lota, Rupinder, Dhanani, Sachin, Owen, Caroline and Ahmed, Sabbir (2007) Search for potential non-steroidal inhibitors of 17 beta-hydroxysteroid dehydrogenase (170-HSD) in the treatment of hormone-dependent cancers. Letters in Drug Design and Discovery, 4(3), pp. 180-184. ISSN (print) 1570-1808

Patel, Chirag H., Dhanani, Sachin, Owen, Caroline P. and Ahmed, Sabbir (2006) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17[alpha]-hydroxylase/17,20-lyase (P450[sub]17[alpha]). Bioorganic & Medicinal Chemistry Letters, 16(18), pp. 4752-4756. ISSN (print) 0960-894X

Lota, Rupinder K., Dhanani, Sachin, Owen, Caroline P. and Ahmed, Sabbir (2006) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17[beta]-hydroxysteroid dehydrogenase type 3 (17[beta]-HSD3). Bioorganic & Medicinal Chemistry Letters, 16(17), pp. 4519-4522. ISSN (print) 0960-894X

Owen, Caroline P, Dhanani, Sachin, Patel, Chirag H, Shahid, Imran and Ahmed, Sabbir (2006) Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17[alpha]-hydroxylase/17,20-lyase (P450[sub]17[alpha]). Bioorganic & Medicinal Chemistry Letters, 16(15), pp. 4011-4015. ISSN (print) 0960-894X

Owen, Caroline P. and Ahmed, Sabbir (2004) The derivation of a potential transition state for the reduction reaction catalysed by 17[beta]-hydroxysteroid dehydrogenase--an approximate representation of its active site for use in drug design and discovery. Biochemical and Biophysical Research Communications, 318(1), pp. 131-134. ISSN (print) 0006-291X

Patel, Chirag K., Owen, Caroline P. and Ahmed, Sabbir (2004) Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorganic & Medicinal Chemistry Letters, 14(3), pp. 605-609. ISSN (print) 0960-894X

Patel, Chirag K., Owen, Caroline P. and Ahmed, Sabbir (2003) The design, synthesis, and in vitro biochemical evaluation of a series of esters of 4-[(aminosulfonyl)oxy]benzoate as novel and highly potent inhibitors of estrone sulfatase. Biochemical and Biophysical Research Communications, 307(4), pp. 778-781. ISSN (print) 0006-291X

Patel, C.K., Galisson, A., James, K., Owen, C.P. and Ahmed, S. (2003) Structure-activity relationship determination within a group of substituted phenyl sulfamate based compounds against the enzyme oestrone sulfatase. Journal of Pharmacy and Pharmacology, 55(2), pp. 211-218. ISSN (print) 0022-3573

Owen, C., James, K., Sampson, L. and Ahmed, S. (2003) Synthesis and biochemical evaluation of some novel benzoic acid based esters as potential inhibitors of oestrone sulphatase. Journal of Pharmacy and Pharmacology, 55(1), pp. 85-93. ISSN (print) 0022-3573

Ahmed, Sabbir, James, Karen and Owen, Caroline P. (2002) Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). The Journal of Steroid Biochemistry and Molecular Biology, 82(4-5), pp. 425-435. ISSN (print) 0960-0760

Ahmed, Sabbir, Adat, Shaheen, Murrells, Annabel, Owen, Caroline P and Amanuel, Yonas (2002) Design, synthesis, and evaluation of 4-(4'-aminobenzyl)-2-oxazolidinones as novel inhibitors of the cytochrome P-450 enzyme aromatase. Bioorganic Chemistry, 30(5), pp. 315-331. ISSN (print) 0045-2068

Ahmed, Sabbir, James, Karen and Owen, Caroline P. (2002) Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorganic & Medicinal Chemistry Letters, 12(17), pp. 2391-2394. ISSN (print) 0960-894X

Ahmed, Sabbir, Adat, Shaheen, Murrells, Annabel and Owen, Caroline P. (2002) Novel oxazolidinone based compounds as inhibitors of aromatase and the use of the substrate-heme complex approach in the rationalisation of these compounds. Biochemical and Biophysical Research Communications, 294(2), pp. 380-383. ISSN (print) 0006-291X

Ahmed, Sabbir, James, Karen, Owen, Caroline P. and Patel, Chirag K. (2002) Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 12(10), pp. 1343-1346. ISSN (print) 0960-894X

Ahmed, Sabbir, James, Karen, Owen, Caroline P., Patel, Chirag K. and Sampson, Luther (2002) The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds. Bioorganic & Medicinal Chemistry Letters, 12(9), pp. 1279-1282. ISSN (print) 0960-894X

Ahmed, Sabbir, Owen, Caroline P., James, Karen, Patel, Chirag K. and Sampson, Luther (2002) Evidence for the mechanism of the irreversible inhibition of oestrone sulphatase (ES) by aminosulphonate based compounds. The Journal of Steroid Biochemistry and Molecular Biology, 80(4-5), pp. 429-440. ISSN (print) 0960-0760

Ahmed, Sabbir, James, Karen, Owen, Caroline P. and Patel, Chirag K. (2002) Synthesis and biochemical evaluation of novel and potent inhibitors of the enzyme oestrone sulphatase (ES). The Journal of Steroid Biochemistry and Molecular Biology, 80(4-5), pp. 419-427. ISSN (print) 0960-0760

Ahmed, S., Owen, C.P., James, K., Sampson, L. and Patel, C.K. (2002) Review of estrone sulfatase and its inhibitors: an important new target against hormone dependent breast cancer. Current medicinal chemistry, 9(2), pp. 263-273. ISSN (print) 0929-8673

Ahmed, Sabbir, James, Karen, Owen, Caroline P., Patel, Chirag K. and Patel, Mijal B. (2001) Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism. Bioorganic & Medicinal Chemistry Letters, 11(23), pp. 3001-3005. ISSN (print) 0960-894X

Ahmed, Sabbir, James, Karen, Owen, Caroline P., Patel, Chirag and Patel, Mijal (2001) Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 11(18), pp. 2525-2528. ISSN (print) 0960-894X

Ahmed, Sabbir, Owen, Caroline P., James, Karen, Patel, Chirag K. and Patel, Mijal (2001) Acid dissociation constant, a potential physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 11(7), pp. 899-902. ISSN (print) 0960-894X

Ahmed, Sabbir, James, Karen, Owen, Caroline P., Patel, Chirag and Patel, Mijal (2001) Novel inhibitors of the enzyme estrone sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 11(6), pp. 841-844. ISSN (print) 0960-894X

Ahmed, Sabbir and Owen, Caroline P. (1998) Mechanism of 17[alpha]-hydroxylase/17,20-lyase--an initial geometric perspective for the lyase of the C(17)-C(20) bond of C[sub]21 steroids. Bioorganic & Medicinal Chemistry Letters, 8(9), pp. 1023-1028. ISSN (print) 0960-894X

This list was generated on Fri Oct 24 10:37:41 2014 BST.