Ahmed, Sabbir and Keane, Jason (1998) Modeling study of some inhibitors of 17,20-lyase, a component of the enzyme 17[alpha]-hydroxylase/17,20-lyase: a novel approach. Biochemical and Biophysical Research Communications, 253(2), pp. 273-276. ISSN (print) 0006-291XFull text not available from this archive.
A novel molecular modeling study, involving inhibitors bound to a "substrate-heme complex," is described for the binding of steroidal and non-steroidal inhibitors of the 17,20-Lyase component of the enzyme complex 17 alpha-hydroxylase/17,20-lyase to gain further insight into the active site of this enzyme. This novel approach has resulted in the construction of a simple working model using which a number of compounds and their inhibitory activity have been rationalised.
|Faculty, School or Research Centre:||Faculty of Science (until 2011) > School of Pharmacy and Chemistry|
|Depositing User:||Automatic Import Agent|
|Date Deposited:||18 Mar 2010 14:31|
|Last Modified:||14 Apr 2011 12:19|
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