Ahmed, Sabbir and Keane, Jason (1998) Modeling study of some inhibitors of 17,20-lyase, a component of the enzyme 17[alpha]-hydroxylase/17,20-lyase: a novel approach. Biochemical and Biophysical Research Communications, 253(2), pp. 273-276. ISSN (print) 0006-291X
Full text not available from this archive.Abstract
A novel molecular modeling study, involving inhibitors bound to a "substrate-heme complex," is described for the binding of steroidal and non-steroidal inhibitors of the 17,20-Lyase component of the enzyme complex 17 alpha-hydroxylase/17,20-lyase to gain further insight into the active site of this enzyme. This novel approach has resulted in the construction of a simple working model using which a number of compounds and their inhibitory activity have been rationalised.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ketoconazole |
| Research Area: | Chemistry |
| Faculty, School or Research Centre: | Faculty of Science (until 2011) > School of Pharmacy and Chemistry |
| Related URLs: | |
| Depositing User: | Automatic Import Agent |
| Date Deposited: | 18 Mar 2010 14:31 |
| Last Modified: | 14 Apr 2011 12:19 |
| URI: | http://eprints.kingston.ac.uk/id/eprint/7276 |
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