Derivation of a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES)

Ahmed, Sabbir and James, Karen (1999) Derivation of a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 9(12), pp. 1645-1650. ISSN (print) 0960-894X

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Abstract

We have determined a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES) - as a representation of the active site. Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.

Item Type: Article
Uncontrolled Keywords: steroid sulfatase, estrone-3-o-sulfamate, inhibitors
Research Area: Chemistry
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Pharmacy and Chemistry
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Depositing User: Automatic Import Agent
Date Deposited: 16 Mar 2010 11:43
Last Modified: 14 Apr 2011 11:59
URI: http://eprints.kingston.ac.uk/id/eprint/7266

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