Ahmed, Sabbir and James, Karen (1999) Derivation of a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 9(12), pp. 1645-1650. ISSN (print) 0960-894X
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Official URL: http://dx.doi.org/10.1016/S0960-894X(99)00245-0
Abstract
We have determined a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES) - as a representation of the active site. Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | steroid sulfatase, estrone-3-o-sulfamate, inhibitors |
| Research Area: | Chemistry |
| Faculty, School or Research Centre: | Faculty of Science (until 2011) > School of Pharmacy and Chemistry |
| Related URLs: | |
| Depositing User: | Automatic Import Agent |
| Date Deposited: | 16 Mar 2010 11:43 |
| Last Modified: | 14 Apr 2011 11:59 |
| URI: | http://eprints.kingston.ac.uk/id/eprint/7266 |
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