Ahmed, Sabbir and James, Karen (1999) Derivation of a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 9(12), pp. 1645-1650. ISSN (print) 0960-894XFull text not available from this archive.
We have determined a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES) - as a representation of the active site. Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.
|Uncontrolled Keywords:||steroid sulfatase, estrone-3-o-sulfamate, inhibitors|
|Faculty, School or Research Centre:||Faculty of Science (until 2011) > School of Pharmacy and Chemistry|
|Depositing User:||Automatic Import Agent|
|Date Deposited:||16 Mar 2010 11:43|
|Last Modified:||14 Apr 2011 11:59|
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