Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides

Page, N. M. (2006) Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides. Vascular Pharmacology, 45(4), pp. 200-208. ISSN (print) 1537-1891

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Abstract

The endokinins represent several species-divergent and peripherally located mammalian tachykinins (hemokinin-1 in mouse and rat, endokinin-1 in rabbit and endokinins A and B in humans) and also the tachykinin gene-related peptides. These peptides are all encoded on the preprotachykinin 4 (TAC4) gene. Their complementary DNA sequences, gene structures and expression profiles have been determined from a number of different mammalian species. They are all flanked by adjacent upstream and downstream dibasic cleavage sites in their respective precursor proteins, except for human EKA/B that instead possesses a N-terminal monobasic cleavage site. Evidence for differential processing in the periphery at the N-terminal cleavage site of the tachykinins could explain why in humans the evolutionary pressure to maintain the N-terminal dibasic cleavage site of EKA/B has been lost. Furthermore, the TAC4 encoded tachykinins all exhibit a remarkable selectivity and potency for the highly species conserved tachykinin NK(1) receptor, similar to that of substance P. Particular consideration is also given to the potential interactions of the endokinins with the short NK(1) receptor isoform and to speculation of whether there could be an "endokinin-sensitive" NK(1) binding site.

Item Type: Article
Uncontrolled Keywords: tachykinin, hemokinin, neurokinin, processing, peptide
Research Area: Allied health professions and studies
Biological sciences
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Life Sciences
Related URLs:
Depositing User: Nigel Page
Date Deposited: 22 Jun 2009 12:57
Last Modified: 17 Feb 2010 11:38
URI: http://eprints.kingston.ac.uk/id/eprint/5358

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