Effect of non-cross-linked calcium on characteristics, swelling behaviour, drug release and mucoadhesiveness of calcium alginate beads

Dalaty, Adnan Al, Karam, Ayman, Najlah, Mohammad, Alany, Raid G. and Khoder, Mouhamad (2016) Effect of non-cross-linked calcium on characteristics, swelling behaviour, drug release and mucoadhesiveness of calcium alginate beads. Carbohydrate Polymers, 140, pp. 163-170. ISSN (print) 0144-8617

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Abstract

In this study, ibuprofen-loaded calcium alginate beads (CABs) with varying amounts of non-cross-linked calcium (NCL-Ca) were prepared using different washing methods. The influence of NCL-Ca on beads properties was investigated. Increasing the number or duration of washes led to significant decreases in the amount of NCL-Ca whereas the impact of the volume of washes was not significant. Approximately 70% of the initial amount of Ca(2+) was NCL-Ca which was removable by washing while only 30% was cross-linked (CL-Ca). Ca(2+) release from the CABs was bimodal; NCL-Ca was burst-released followed by a slower release of CL-Ca. Washing methods and the amount of NCL-Ca had significant influences on the encapsulation efficiency, beads weight, beads swelling, drug release profile and the mucoadhesiveness of CABs. This study highlighted the importance of washing methods and the amount of NCL-Ca to establish CABs properties and understand their behaviour in the simulated intestinal fluids (SIFs).

Item Type: Article
Uncontrolled Keywords: calcium alginate beads, cross-linked calcium, non-cross-linked calcium, encapsulation efficiency, mucoadhesiveness, drug release
Research Area: Chemistry
Pharmacy
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Pharmacy and Chemistry
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Depositing User: Anna Englund
Date Deposited: 11 Jan 2016 16:34
Last Modified: 01 Feb 2017 03:31
URI: http://eprints.kingston.ac.uk/id/eprint/33742

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