New generation of orally disintegrating tablets for sustained drug release: a propitious outlook

Elwerfalli, A.M., Ghanchi, Z., Rashid, F., Alany, R. and ElShaer, A. (2016) New generation of orally disintegrating tablets for sustained drug release: a propitious outlook. Current Drug Delivery, 12(6), pp. 652-667. ISSN (print) 1567-2018

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Abstract

Orally disintegrating tablets (ODTs) or orodispersible tablets are solid dosage forms that disintegrate within 3 minutes in the mouth into a paste that can be easily swallowed. ODTs have improved over the past years, in an attempt to produce a safe and efficient substitute to the conventional oral dosage forms, particularly for dysphagia patients. Since its introduction in the market in the 1980s, ODTs expanded rapidly and achieved revenues over $3 billion in 2006 and sustaining 20% annual growth. It is therefore evident that ODTs carry good commercial value, however there is potential for improvement. Current sustained-release technologies may be exploited and incorporated into an ODT to provide greater therapeutic value by reducing the need for multiple daily dosing regimens and improving patient adherence. A number of technologies such as polymer coated nanoparticles, stimuli-responsive polymers and ion-exchange resins have emerged to produce robust, sustained release orally disintegrating tablets (SR-ODT). The purpose of this review is to highlight these various approaches and techniques and how they have been utilised in an ODT formulation to extend differentiated line, market exclusivity and patent life. The review will also look at future prospective and the potential challenges that will face SR-ODTs.

Item Type: Article
Uncontrolled Keywords: encapsulation, ion-exchange resin, market contribution, nanoparticles, odts, sustained release
Research Area: Pharmacy
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing
Faculty of Science, Engineering and Computing > School of Pharmacy and Chemistry
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Depositing User: Automatic Import Agent
Date Deposited: 18 Mar 2015 19:27
Last Modified: 09 May 2016 10:51
URI: http://eprints.kingston.ac.uk/id/eprint/30652

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