Association of KIBRA rs17070145 polymorphism with episodic memory in the early stages of a human neurodevelopmental disorder

Vyas, Nora S, Ahn, Kwangmi, Stahl, Daniel R, Caviston, Paul, Simic, Mima, Netherwood, Siobhan, Puri, Basant K, Lee, Yohan and Aitchison, Katherine J (2014) Association of KIBRA rs17070145 polymorphism with episodic memory in the early stages of a human neurodevelopmental disorder. Psychiatry Research, 220(1-2), pp. 37-43. ISSN (print) 0165-1781

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Abstract

A common T/C polymorphism within the ninth intron of the KIBRA gene (rs17070145) is thought to influence memory in humans. Since cognitive impairment, including memory, is a core feature of schizophrenia, we attempted to investigate this association in an independent sample of adolescent patients with early-onset schizophrenia (EOS; onset before age 18) probands and their healthy siblings. In a sample of 25 pairs of EOS proband-healthy full sibling, we sought to investigate the association of KIBRA with memory performance. Episodic memory was measured using immediate and delayed recall measures of the California Verbal Learning Test. EOS underperformed at immediate and delayed recall compared with siblings. In a combined analysis (TT vs. TC/CC) assuming a C dominant model of inheritance, we found a main effect of genotype where individuals with TT genotype outperformed non-TT-carriers at immediate and delayed recall. A genotype by group interaction showed that EOS with TT genotype did not show a memory advantage over siblings with TT or non-TT-carriers at immediate or delayed recall. Siblings with TT genotype showed enhanced immediate recall (not delayed recall) compared with non-TT-carriers. This study demonstrates an association between the KIBRA gene and episodic memory (immediate free recall) and suggests a differential effect of this genetic variant in EOS and healthy siblings.

Item Type: Article
Uncontrolled Keywords: adolescent, KIBRA, schizophrenia, WWC1 protein, memory, polymorphism
Research Area: Psychiatry, neuroscience and clinical psychology
Psychology
Faculty, School or Research Centre: Faculty of Arts and Social Sciences > School of Psychology, Criminology and Sociology (from November 2012)
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Depositing User: Automatic Import Agent
Date Deposited: 24 Nov 2014 12:23
Last Modified: 15 Jun 2015 15:31
URI: http://eprints.kingston.ac.uk/id/eprint/29050

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