Evaluation of the stability profile of anticancer drugs: a review of Ifosfamide and Mesna regimen for the treatment of metastatic soft tissue sarcoma

Salman, Dahlia, Swinden, Julian, Barton, Stephen, Peron, Jean-Marie and Nabhani-Gebara, Shereen (2016) Evaluation of the stability profile of anticancer drugs: a review of Ifosfamide and Mesna regimen for the treatment of metastatic soft tissue sarcoma. Journal of Oncology Pharmacy Practice, 22(1), pp. 86-91. ISSN (print) 1078-1552

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Abstract

Purpose: This paper aims to summarise and critically review the existing published literature with regard to clinical considerations as well as stability testing studies of Ifosfamide and Mesna. It also aims to highlight the factors that should be considered when designing and conducting stability testing experiments. Summary: Ifosfamide and Mesna are currently given to patients for 14 days continuous home-based infusion for the treatment of soft tissue sarcoma. No previous work has evaluated their stability for more than 7 days under real-life conditions so the current regimen involves patients visiting hospital twice during the 14-day treatment. This may create extra disruption to patients’ life style as well as increasing the workload for cancer services. Conclusion: There is a need to conduct stability testing experiments for Ifosfamide and Mesna taking into consideration all of the highlighted factors to mimic standard clinical practice.

Item Type: Article
Uncontrolled Keywords: sarcoma, elastomeric pumps, infusion, ifosfamide, mesna
Research Area: Pharmacy
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Pharmacy and Chemistry
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Depositing User: Automatic Import Agent
Date Deposited: 03 Nov 2014 14:16
Last Modified: 20 May 2016 08:52
URI: http://eprints.kingston.ac.uk/id/eprint/29047

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