Preferential survival of acute lymphoblastic leukemia cells at 33[sup] [degrees]C is associated with up-regulation of bcl-2

Morsi, H., Yong, K.L. and Jewell, A.P. (2006) Preferential survival of acute lymphoblastic leukemia cells at 33[sup] [degrees]C is associated with up-regulation of bcl-2. Leukemia and Lymphoma, 47(6), pp. 1117-1122. ISSN (print) 1042-8194

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Abstract

An important feature of childhood acute lymphoblastic leukemia (ALL) is the risk of testicular relapse in affected males, which may occur months or years after induction of remission. However, little is known about the factors that regulate leukemic cell survival and resistance to chemotherapy in the testis. In the present study, incubating ALL cell lines and primary cells from ALL patients at 33 degrees C resulted in increased survival, resistance to chemotherapeutic agents and upregulation of bcl-2. Acute myeloid leukemia cell lines incubated at 33 degrees C also showed increased survival and resistance to chemotherapeutic agents, but did not demonstrate upregulation of bcl-2. This may be important in determining survival of ALL cells at lower temperatures in the testis.

Item Type: Article
Uncontrolled Keywords: acute lymphoblastic leukemia, testicular relapse, bcl-2, induced apoptosis, oxidative stress, hypothermia, expression, protects
Research Area: Cancer studies
Other hospital based clinical subjects
Faculty, School or Research Centre: Faculty of Health and Social Care Sciences
Related URLs:
Depositing User: Mark Brennan
Date Deposited: 07 Aug 2008
Last Modified: 29 Jun 2010 09:06
URI: http://eprints.kingston.ac.uk/id/eprint/2741

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