Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner.

Waheed, A., Ludtmann, M.H.R., Pakes, N., Robery, S., Kuspa, A., Dinh, C., Baines, D., Williams, R.S.B. and Carew, M. (2014) Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner. British Journal of Pharmacology, 171(10), pp. 2659-2670. ISSN (print) 0007-1188

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Abstract

The action of naringenin on cell growth in the phylogenetically diverse systems of Dictyostelium and mammalian kidney cells, suggests a conserved effect mediated by polycystin-2 (TRPP2). Further studies will investigate naringenin as a potential new therapeutic agent in ADPKD.

Item Type: Article
Uncontrolled Keywords: polycystic kidney disease, polycystin-2, naringenin, dictyostelium, polyphenol, cell growth
Research Area: Pharmacy
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing
Faculty of Science, Engineering and Computing > School of Pharmacy and Chemistry
Depositing User: Automatic Import Agent
Date Deposited: 16 May 2014 12:48
Last Modified: 17 Jul 2014 15:00
URI: http://eprints.kingston.ac.uk/id/eprint/26651

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