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Recent patents and trends in orally disintegrating tablets

AlHusban, Farhan A, El-Shaer, Amr M, Jones, Rhys J and Mohammed, Afzal R (2010) Recent patents and trends in orally disintegrating tablets. Recent Patents on Drug Delivery & Formulation, 4(3), pp. 178-197. ISSN (print) 1872-2113

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Abstract

Orally disintegrating tablets (ODTs) offer many advantages over the conventional oral dosage forms in terms of convenience and ease of use. Over the last decade, substantial advances in the formulation of ODTs have been achieved in academia and industry that resulted in the emerging of a large number of patents. The aim of this review is to summarise the most recent patents in ODT formulations and highlight their motivations, inventive steps and significances in the development of ODT formulations. Five major techniques have been applied in manufacturing of ODTs, namely conventional tablet press, moulding, freeze drying, tablet loading and pulverization, with majority of the patents dedicated to the use of conventional tablet pressing. The patents have addressed various issues concerning the manufacturing of robust and practical ODT formulations by disclosing new manufacturing techniques, advantageous materials, and innovative formulation steps. However, future developments are required to reduce the cost and widening the application of the new manufacturing techniques, while simplifying and shortening the formulation steps will be crucial in the well established ones.

Item Type: Article
Research Area: Chemistry
Pharmacy
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Pharmacy and Chemistry
Related URLs:
Depositing User: Amr ElShaer
Date Deposited: 13 Feb 2014 13:53
Last Modified: 13 Feb 2014 13:53
URI: http://eprints.kingston.ac.uk/id/eprint/26567

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