Dietary chelators as antioxidant enzyme mimetics: implications for dietary intervention in neurodegenerative diseases

Hague, Theresa, Andrews, Paul L.R., Barker, James and Naughton, Declan P. (2006) Dietary chelators as antioxidant enzyme mimetics: implications for dietary intervention in neurodegenerative diseases. Behavioural Pharmacology, 17(5-6), pp. 425-430. ISSN (print) 0955-8810

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Abstract

Following recent reviews on the role of metal ions in oxidative stress and neurodegenerative diseases, this article reports advances in the study of dietary components for the control of these conditions. Poor metal ion homeostasis is credited with pathological roles in the progression of a number of disorders including Alzheimer's disease, Parkinson's disease and multiple sclerosis. Synthetic metal ion chelators continue to show promise as a new therapeutic approach for neurodegenerative disorders. Dietary chelators, unlike most vitamins, are, however, capable of negating or even reversing the roles of metal ions by: (i) decorporation of metal ions, (ii) redox silencing, (iii) dissolution of deposits, and (iv) generation of an antioxidant enzyme mimetic. This review gives a critical evaluation of recent progress in, and potential for, dietary control of neurodegeneration on the basis of the formation of antioxidant enzyme mimetics.

Item Type: Article
Uncontrolled Keywords: antioxidant enzyme mimetic, chelator, diet, metal ions, natural product, neurodegeneration, oxidative stress, amyloid precursor protein, alzheimers-disease, superoxide-dismutase, parkinsons-disease, oxidative-stress, green tea, in-vivo, epigallocatechin gallate, reperfusion injury, substantia-nigra
Faculty, School or Research Centre: Faculty of Science (until 2011) > School of Life Sciences
Faculty of Science (until 2011) > School of Pharmacy and Chemistry
Faculty of Science (until 2011)
Depositing User: Declan Naughton
Date Deposited: 09 May 2008
Last Modified: 05 Oct 2010 10:17
URI: http://eprints.kingston.ac.uk/id/eprint/2354

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