Hypoxia in pre-eclampsia: cause or effect?

Karanam, Vijaya, Page, Nigel and Anim-Nyame, Nick (2010) Hypoxia in pre-eclampsia: cause or effect? Current Women's Health Reviews, 6(4), pp. 303-308. ISSN (print) 1573-4048

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Abstract

Pre-eclampsia is a pregnancy specific multi-system disorder associated with increased maternal and perinatal morbidity and mortality. In spite of intensive research for several decades into its pathophysiology, the aetiology remains unexplained. There is evidence that maternal tissue blood flow is reduced in pregnancies complicated by this disease, which precedes clinical onset, and persists after delivery. It is however unclear whether the reduced maternal tissue blood flow is associated with changes in tissue oxygenation and/or abnormal tissue oxygen homeostasis and whether this precedes or follows pre-eclampsia. This review examines the cause and effect relationship between hypoxia and pre-eclampsia and possible underlying mechanism(s) of impairment in oxygen regulation.

Item Type: Article
Research Area: Allied health professions and studies
Biological sciences
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing
Faculty of Science, Engineering and Computing > School of Life Sciences
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Depositing User: Nigel Page
Date Deposited: 16 Nov 2011 11:52
Last Modified: 16 Nov 2011 11:52
URI: http://eprints.kingston.ac.uk/id/eprint/21301

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