Calabrese, Gianpiero, Nesnas, John J, Barbu, Eugen, Fatouros, Dimitris and Tsibouklis, John (2012) The formulation of polyhedral boranes for the boron neutron capture therapy of cancer. Drug Discovery Today, 17(3-4), pp. 153-159. ISSN (print) 1359-6446
Full text not available from this archive.Abstract
The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of (10)B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action - the subject of this review - is a challenge that is addressed by the development of innovative formulation strategies.
| Item Type: | Article |
|---|---|
| Research Area: | Cancer studies |
| Faculty, School or Research Centre: | Faculty of Science, Engineering and Computing > School of Pharmacy and Chemistry |
| Related URLs: | |
| Depositing User: | Automatic Import Agent |
| Date Deposited: | 14 Oct 2011 08:48 |
| Last Modified: | 07 Jan 2013 11:27 |
| URI: | http://eprints.kingston.ac.uk/id/eprint/21159 |
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