The formulation of polyhedral boranes for the boron neutron capture therapy of cancer

Calabrese, Gianpiero, Nesnas, John J, Barbu, Eugen, Fatouros, Dimitris and Tsibouklis, John (2012) The formulation of polyhedral boranes for the boron neutron capture therapy of cancer. Drug Discovery Today, 17(3-4), pp. 153-159. ISSN (print) 1359-6446

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Abstract

The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of (10)B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action - the subject of this review - is a challenge that is addressed by the development of innovative formulation strategies.

Item Type: Article
Research Area: Cancer studies
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Pharmacy and Chemistry
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Depositing User: Automatic Import Agent
Date Deposited: 14 Oct 2011 08:48
Last Modified: 07 Jan 2013 11:27
URI: http://eprints.kingston.ac.uk/id/eprint/21159

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