The role of muscle weakness in the pathogenesis of osteoarthritis

Hurley, Michael V. (1999) The role of muscle weakness in the pathogenesis of osteoarthritis. Rheumatic Diseases Clinics of North America, 25(2), pp. 283-298. ISSN (print) 0889-857X

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Abstract

To date, very few studies have investigated the role of muscle dysfunction in the pathogenesis of osteoarthritis (OA). Using largely indirect evidence, this article hypothesizes that motor and sensory dysfunction of muscle may be important factors in the pathogenesis of articular damage and are not simply a consequence of joint damage. A new paradigm is constructed to better describe the complex interrelationship between muscle sensorimotor dysfunction, joint damage, and disability in OA. If the hypothesis is correct, because muscle is a relatively plastic tissue, maintaining well-conditioned muscles may delay or prevent the onset of OA, and rehabilitation exercise therapy that reverses muscle sensorimotor dysfunction may ameliorate the effects of OA.

Item Type: Article
Research Area: Allied health professions and studies
Health services research
Faculty, School or Research Centre: Faculty of Health and Social Care Sciences
Depositing User: Katrina Clifford
Date Deposited: 18 Nov 2010 12:15
Last Modified: 18 Nov 2010 12:15
URI: http://eprints.kingston.ac.uk/id/eprint/17336

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