Research at Kingston University

Article

Waheed, Abdul, Barker, James, Barton, Stephen J, Owen, Caroline P, Ahmed, Sabbir and Carew, Mark A (2012) A novel steroidal saponin glycoside from Fagonia indica induces cell-selective apoptosis or necrosis in cancer cells. European Journal of Pharmaceutical Sciences, 47(2), pp. 464-473. ISSN (print) 0928-0987

AHMED, SABBIR, Shahid, Imran, Bhatti, Kishore, Lee, Wai-Yee and Owen, Caroline (2009) Synthesis and Biochemical Evaluation of a Range of 2-, 3-and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17 alpha-hydroxylase/17,20-Lyase (P450(17 alpha)). Letters in Drug Design and Discovery, 6(7), pp. 524-530. ISSN (print) 1570-1808

Shah, Kruti, Olusanjo, Moniola S., Cartledge, Tim, Owen, Caroline P. and Ahmed, Sabbir (2009) Synthesis and biochemical evaluation of a series of methanesulfonate derivatives of 4-hydroxyphenyl ketone as probes of the active site of type 3 OF 17[beta]-hydroxysteroid dehydrogenase family of enzymes. Letters in Drug Design and Discovery, 6(7), pp. 518-523. ISSN (print) 1570-1808

Ahmed, Sabbir, Shahid, Imran, Dhanani, Sachin and Owen, Caroline P. (2009) Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17 alpha-hydroxylase/17,20-lyase (P-450(17 alpha)). Bioorganic & Medicinal Chemistry Letters, 19(16), pp. 4698-4701. ISSN (print) 0960-894X

Aidoo-Gyamfi, Kwabina, Cartledge, Tim, Shah, Kruti and Ahmed, Sabbir (2009) Estrone sulfatase and its inhibitors. Anti-Cancer Agents in Medicinal Chemistry, 9(6), pp. 599-612. ISSN (print) 1871-5206

Lota, Rupinder K., Olusanjo, Moniola S., Dhanani, Sachin, Owen, Caroline P. and Ahmed, Sabbir (2008) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-hydroxyphenyl ketones as potent and specific inhibitors of the type 3 of 17[beta]-hydroxysteroid dehydrogenase (17[beta]-HSD3). The Journal of Steroid Biochemistry and Molecular Biology, 111(1-2), pp. 128-137. ISSN (print) 0960-0760

Owen, Caroline P., Shahid, Imran, Olusanjo, Moniola S, Patel, Chirag H., Dhanani, Sachin and Ahmed, Sabbir (2008) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17[alpha]-hydroxylase/17,20-lyase (P450(17[alpha])). The Journal of Steroid Biochemistry and Molecular Biology, 111(1-2), pp. 117-127. ISSN (print) 0960-0760

Shahid, Imran, Patel, Chirag H., Dhanani, Sachin, Owen, Caroline P. and Ahmed, Sabbir (2008) Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17[alpha]-Hydroxylase/17,20-Lyase (P450[sub]17[alpha]). The Journal of Steroid Biochemistry and Molecular Biology, 110(1-2), pp. 18-29. ISSN (print) 0960-0760

Olusanjo, Moniola, Shahid, Imran, Owen, Caroline P. and Ahmed, Sabbir (2008) Inhibition of 17β -Hydroxysteroid Dehydrogenase (17β -HSD) by Imidazole-Based Compounds. Letters in Drug Design and Discovery, 5(1), pp. 48-51. ISSN (print) 1570-1808

Adat, Shaheen, Owen, Caroline P. and Ahmed, Sabbir (2007) Inhibition of aromatase (AR) by benzyl azole-based compounds. Letters in Drug Design and Discovery, 4(8), pp. 545-549. ISSN (print) 1570-1808

Olusanjo, Moniola and Ahmed, Sabbir (2007) The Derivation of a Potential Transition-State for the Reduction Reaction Catalysed by 17β -Hydroxysteroid Dehydrogenase Type 3 (17β -HSD) - An Approximate Representation of its Active Site for Use in Drug Design and Discovery. Letters in Drug Design and Discovery, 4(7), pp. 527-531. ISSN (print) 1570-1808

Owen, Caroline, Dhanani, Sachin, Patel, Chirag and Ahmed, Sabbir (2007) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-substituted phenyl alkyl triazole-based compounds as potential inhibitors of 17 alpha-hydroxylase/17,20-lyase (P450(17 alpha)). Letters in Drug Design and Discovery, 4(7), pp. 479-483. ISSN (print) 1570-1808

Owen, Caroline, Patel, Mijal, Patel, Chirag, Cartledge, Tim and Ahmed, Sabbir (2007) Synthesis and in vitro biochemical evaluation of a series of compounds as potential inhibitors of estrone sulfatase (ES) and the role of pK(a) in both the synthesis and the inhibitory activity of the potential inhibitors. Letters in Drug Design and Discovery, 4(6), pp. 394-398. ISSN (print) 1570-1808

Owen, Caroline, Patel, Chirag, Cartledge, Tim and Ahmed, Sabbir (2007) Synthesis and in vitro biochemical evaluation of a series of cycloalkyl esters of 4-sulfamoylated benzoic acid as inhibitors of estrone sulfatase (ES). Letters in Drug Design and Discovery, 4(6), pp. 399-403. ISSN (print) 1570-1808

Lota, Rupinder, Dhanani, Sachin, Owen, Caroline and Ahmed, Sabbir (2007) Search for potential non-steroidal inhibitors of 17 beta-hydroxysteroid dehydrogenase (170-HSD) in the treatment of hormone-dependent cancers. Letters in Drug Design and Discovery, 4(3), pp. 180-184. ISSN (print) 1570-1808

Patel, Chirag H., Dhanani, Sachin, Owen, Caroline P. and Ahmed, Sabbir (2006) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17[alpha]-hydroxylase/17,20-lyase (P450[sub]17[alpha]). Bioorganic & Medicinal Chemistry Letters, 16(18), pp. 4752-4756. ISSN (print) 0960-894X

Lota, Rupinder K., Dhanani, Sachin, Owen, Caroline P. and Ahmed, Sabbir (2006) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17[beta]-hydroxysteroid dehydrogenase type 3 (17[beta]-HSD3). Bioorganic & Medicinal Chemistry Letters, 16(17), pp. 4519-4522. ISSN (print) 0960-894X

Owen, Caroline P, Dhanani, Sachin, Patel, Chirag H, Shahid, Imran and Ahmed, Sabbir (2006) Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17[alpha]-hydroxylase/17,20-lyase (P450[sub]17[alpha]). Bioorganic & Medicinal Chemistry Letters, 16(15), pp. 4011-4015. ISSN (print) 0960-894X

Owen, Caroline P. and Ahmed, Sabbir (2004) The derivation of a potential transition state for the reduction reaction catalysed by 17[beta]-hydroxysteroid dehydrogenase--an approximate representation of its active site for use in drug design and discovery. Biochemical and Biophysical Research Communications, 318(1), pp. 131-134. ISSN (print) 0006-291X

Ahmed, Sabbir (2004) The use of the novel substrate-heme complex approach in the derivation of a representation of the active site of the enzyme complex 17[alpha]-hydroxylase and 17,20-lyase. Biochemical and Biophysical Research Communications, 316(3), pp. 595-598. ISSN (print) 0006-291X

Patel, Chirag K., Owen, Caroline P. and Ahmed, Sabbir (2004) Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorganic & Medicinal Chemistry Letters, 14(3), pp. 605-609. ISSN (print) 0960-894X

Patel, Chirag K., Owen, Caroline P. and Ahmed, Sabbir (2003) The design, synthesis, and in vitro biochemical evaluation of a series of esters of 4-[(aminosulfonyl)oxy]benzoate as novel and highly potent inhibitors of estrone sulfatase. Biochemical and Biophysical Research Communications, 307(4), pp. 778-781. ISSN (print) 0006-291X

Patel, C.K., Galisson, A., James, K., Owen, C.P. and Ahmed, S. (2003) Structure-activity relationship determination within a group of substituted phenyl sulfamate based compounds against the enzyme oestrone sulfatase. Journal of Pharmacy and Pharmacology, 55(2), pp. 211-218. ISSN (print) 0022-3573

Owen, C., James, K., Sampson, L. and Ahmed, S. (2003) Synthesis and biochemical evaluation of some novel benzoic acid based esters as potential inhibitors of oestrone sulphatase. Journal of Pharmacy and Pharmacology, 55(1), pp. 85-93. ISSN (print) 0022-3573

Ahmed, Sabbir, James, Karen and Owen, Caroline P. (2002) Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). The Journal of Steroid Biochemistry and Molecular Biology, 82(4-5), pp. 425-435. ISSN (print) 0960-0760

Ahmed, Sabbir, Adat, Shaheen, Murrells, Annabel, Owen, Caroline P and Amanuel, Yonas (2002) Design, synthesis, and evaluation of 4-(4'-aminobenzyl)-2-oxazolidinones as novel inhibitors of the cytochrome P-450 enzyme aromatase. Bioorganic Chemistry, 30(5), pp. 315-331. ISSN (print) 0045-2068

Ahmed, Sabbir, James, Karen and Owen, Caroline P. (2002) Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorganic & Medicinal Chemistry Letters, 12(17), pp. 2391-2394. ISSN (print) 0960-894X

Ahmed, Sabbir, Adat, Shaheen, Murrells, Annabel and Owen, Caroline P. (2002) Novel oxazolidinone based compounds as inhibitors of aromatase and the use of the substrate-heme complex approach in the rationalisation of these compounds. Biochemical and Biophysical Research Communications, 294(2), pp. 380-383. ISSN (print) 0006-291X

Ahmed, Sabbir, James, Karen, Owen, Caroline P. and Patel, Chirag K. (2002) Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 12(10), pp. 1343-1346. ISSN (print) 0960-894X

Ahmed, Sabbir, James, Karen, Owen, Caroline P., Patel, Chirag K. and Sampson, Luther (2002) The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds. Bioorganic & Medicinal Chemistry Letters, 12(9), pp. 1279-1282. ISSN (print) 0960-894X

Ahmed, Sabbir, Owen, Caroline P., James, Karen, Patel, Chirag K. and Sampson, Luther (2002) Evidence for the mechanism of the irreversible inhibition of oestrone sulphatase (ES) by aminosulphonate based compounds. The Journal of Steroid Biochemistry and Molecular Biology, 80(4-5), pp. 429-440. ISSN (print) 0960-0760

Ahmed, Sabbir, James, Karen, Owen, Caroline P. and Patel, Chirag K. (2002) Synthesis and biochemical evaluation of novel and potent inhibitors of the enzyme oestrone sulphatase (ES). The Journal of Steroid Biochemistry and Molecular Biology, 80(4-5), pp. 419-427. ISSN (print) 0960-0760

Ahmed, S., Owen, C.P., James, K., Sampson, L. and Patel, C.K. (2002) Review of estrone sulfatase and its inhibitors: an important new target against hormone dependent breast cancer. Current medicinal chemistry, 9(2), pp. 263-273. ISSN (print) 0929-8673

Ahmed, Sabbir, James, Karen, Owen, Caroline P., Patel, Chirag K. and Patel, Mijal B. (2001) Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism. Bioorganic & Medicinal Chemistry Letters, 11(23), pp. 3001-3005. ISSN (print) 0960-894X

Ahmed, Sabbir, James, Karen, Owen, Caroline P., Patel, Chirag and Patel, Mijal (2001) Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 11(18), pp. 2525-2528. ISSN (print) 0960-894X

Ahmed, Sabbir, Owen, Caroline P., James, Karen, Patel, Chirag K. and Patel, Mijal (2001) Acid dissociation constant, a potential physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 11(7), pp. 899-902. ISSN (print) 0960-894X

Ahmed, Sabbir, James, Karen, Owen, Caroline P., Patel, Chirag and Patel, Mijal (2001) Novel inhibitors of the enzyme estrone sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 11(6), pp. 841-844. ISSN (print) 0960-894X

Ahmed, Sabbir (2000) The use of the substrate-heme complex approach in the design, synthesis, biochemical evaluation, and rationalization of the inhibitory activity of a range of azole compounds against cholesterol side chain cleavage enzyme. Biochemical and Biophysical Research Communications, 275(1), pp. 75-76. ISSN (print) 0006-291X

Ahmed, Sabbir (2000) The use of the novel substrate-heme complex approach in the derivation of a representation of the active site of the enzyme cholesterol side chain cleavage. Biochemical and Biophysical Research Communications, 274(3), pp. 821-824. ISSN (print) 0006-291X

Ahmed, Sabbir, James, Karen and Patel, Chirag K. (2000) First report of the investigation into the importance of pK[sub]a in the inhibition of estrone sulfatase by sulfamate containing compounds. Biochemical and Biophysical Research Communications, 272(2), pp. 583-585. ISSN (print) 0006-291X

Ahmed, Sabbir and Amanuel, Yonas (2000) Synthesis and biochemical evaluation of novel inhibitors of aromatase (AR) using an enhanced representation of the active site of AR derived from the consideration of the reaction mechanism. Biochemical and Biophysical Research Communications, 267(1), pp. 356-361. ISSN (print) 0006-291X

Ahmed, Sabbir (1999) A novel molecular modelling study of inhibitors of the 17-[alpha]-hydroxylase component of the enzyme system 17-[alpha]-hydroxylase-17, 20-lyase (P-450[sub](17 [alpha])). Bioorganic & Medicinal Chemistry, 7(8), pp. 1487-1496. ISSN (print) 0968-0896

Ahmed, Sabbir and James, Karen (1999) Derivation of a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 9(12), pp. 1645-1650. ISSN (print) 0960-894X

Ahmed, Sabbir, James, Karen, Sampson, Luther and Mastri, Callii (1999) Structure-activity relationship study of steroidal and nonsteroidal inhibitors of the enzyme estrone sulfatase. Biochemical and Biophysical Research Communications, 254(3), pp. 811-815. ISSN (print) 0006-291X

Ahmed, Sabbir and Keane, Jason (1998) Modeling study of some inhibitors of 17,20-lyase, a component of the enzyme 17[alpha]-hydroxylase/17,20-lyase: a novel approach. Biochemical and Biophysical Research Communications, 253(2), pp. 273-276. ISSN (print) 0006-291X

Ahmed, S. (1998) Review of the molecular modelling studies of the cytochrome P-450 estrogen synthetase enzyme, aromatase. Drug Design and Discovery, 15(4), pp. 239-252. ISSN (print) 1055-9612

Ahmed, Sabbir and Denison, Sophie (1998) Mechanism based representation of the active site of 5-[alpha]-reductase (5AR). Bioorganic & Medicinal Chemistry Letters, 8(18), pp. 2615-2620. ISSN (print) 0960-894X

Ahmed, Sabbir and Owen, Caroline P. (1998) Mechanism of 17[alpha]-hydroxylase/17,20-lyase--an initial geometric perspective for the lyase of the C(17)-C(20) bond of C[sub]21 steroids. Bioorganic & Medicinal Chemistry Letters, 8(9), pp. 1023-1028. ISSN (print) 0960-894X

Ahmed, Sabbir and Denison, Sophie (1998) Structure activity relationship study of known inhibitors of the enzyme 5-[aplha]-reductase (5AR). Bioorganic & Medicinal Chemistry Letters, 8(5), pp. 409-414. ISSN (print) 0960-894X

Ahmed, Sabbir (1998) Aromatase: its mechanism and mode of action of some inhibitors: a molecular modelling perspective. Journal of Molecular Structure THEOCHEM, 422(1-3), pp. 271-284. ISSN (print) 2210-271X

Ahmed, Sabbir (1997) The mechanism of a P-450 enzyme-aromatase; a molecular modelling perspective for the removal of the C(19) methyl and aromatisation of the steroid A ring. Journal of enzyme inhibition, 12(1), pp. 59-70. ISSN (print) 8755-5093

Conference or Workshop Item

Ahmed, S., Owen, C. P., Waheed, A., Nisa, S. [Collaborator], Bibi, Y. [Collaborator] and Chaudhary, M. Fayyaz [Collaborator] (2009) Biochemical evaluation of extracts from Caralluma tuberculata against hormone-dependent breast cancer cells. In: British Pharmaceutical Conference (BPC); 6-9 Sep 2009, Manchester, U.K.. (Journal of Pharmacy and Pharmacology) ISSN (print) 0022-3573

Waheed, A., Cartledge, T., Owen, C.P. and Ahmed, S. (2008) Novel inhibitors of oestrone sulphatase based on the derivatives of 4-aminophenol. In: British Pharmaceutical Conference; 7-9 Sept 2008, Manchester, UK. (Unpublished)

Waheed, A., Aidoo-Gyamfi, K., Owen, C. and Ahmed, S. (2007) The synthesis of a series of amides based upon 4-hydroxybenzoic acid in the development of potential inhibitors of the enzymes oestrone sulphatase. In: The British Pharmaceutical Conference; 10 - 12 Sept 2007, Manchester, U.K..