Platelet monoamine oxidase B activity in Parkinson's disease: a re-evaluation

Jarman, J., Glover, V., Sandler, M., Turjanski, N. and Stern, G. (1993) Platelet monoamine oxidase B activity in Parkinson's disease: a re-evaluation. Journal of Neural Transmission. Parkinson's Disease and Dementia Section, 5(1), pp. 1-4. ISSN (print) 0936-3076

Official URL: http://dx.doi.org/10.1007/BF02260909

Abstract

An increase in platelet monoamine oxidase (MAO) B activity in drug-free parkinsonians (n = 6) compared with healthy controls (n = 10) has been confirmed using both phenylethylamine (PEA) and dopamine as substrates, reaching statistical significance in the case of PEA oxidising activity (p < 0.05). Thus, certain reports of raised platelet MAO B activity towards PEA but decreased activity towards dopamine in parkinsonians, raising the possibility of the existence of an abnormal form of MAO B in this condition, cannot be supported.

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