Ahmed, Sabbir and James, Karen (1999) Derivation of a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES). Bioorganic & Medicinal Chemistry Letters, 9(12), pp. 1645-1650. ISSN (print) 0960-894X
Official URL: http://dx.doi.org/10.1016/S0960-894X(99)00245-0
Abstract
We have determined a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES) - as a representation of the active site. Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.
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