Tubercular uveitis : nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

Testi, Ilaria, Agrawal, Rupesh, Mahajan, Sarakshi, Agarwal, Aniruddha, Gunasekeran, Dinesh Visva, Raje, Dhananjay, Aggarwal, Kanika, Murthy, Somasheila I., Westcott, Mark, Chee, Soon Phaik, McCluskey, Peter, Ho, Su Ling, Teoh, Stephen, Cimino, Luca, Biswas, Jyotirmay, Narain, Shishir, Agarwal, Manisha, Mahendradas, Padmamalini, Khairallah, Moncef, Jones, Nicholas, Tugal-Tutkun, Ilknur, Babu, Kalpana, Basu, Soumayava, Carreno, Ester, Lee, Richard, Al-Dhibi, Hassan, Bodaghi, Bahram, Invernizzi, Alessandro, Goldstein, Debra A., Herbort, Carl P., Barisani-Asenbauer, Talin, González-López, Julio J., Androudi, Sofia, Bansal, Reema, Moharana, Bruttendu, Esposti, Simona Degli, Tasiopoulou, Anastasia, Nadarajah, Sengal, Agarwal, Mamta, Abraham, Sharanya, Vala, Ruchi, Singh, Ramandeep, Sharma, Aman, Sharma, Kusum, Zierhut, Manfred, Rousselot, Andres, Grant, Robert, Kon, Onn Min, Cunningham, Emmett T., Kempen, John, Nguyen, Quan Dong, Pavesio, Carlos and Gupta, Vishali (2019) Tubercular uveitis : nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1. Ocular Immunology and Inflammation, ISSN (print) 0927-3948 (Epub Ahead of Print)


Background: Tuberculosis (TB) is a major infection that can affect the eye as first and sole presentation without features of systemic disease. Controversy exists regarding diagnosis and management of tubercular uveitis (TBU), further compounded by regional variations in disease expression. Purpose: Collaborative Ocular Tuberculosis Study (COTS)-1 aims to address knowledge deficits through collaboration amongst uveitis specialists across the globe by sharing the data of patients with TBU presented at participating centers from January 2004 to December 2014. Methods: Data collection was facilitated by a novel method of real-time encrypted web-based data entry allowing regular updates as new data and recommendations become available. Results: Information on clinical features, investigation findings, management, and treatment outcomes were reviewed to get an idea about real world scenario. Conclusion: The current review aims to focus on methodology and briefing of published reports from COTS group in COTS-1 study to highlight key messages from this large data.

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