HLA-DRB1*15 and pediatric aplastic anemia

Oguz, FS, Yalman, N, Diler, AS, Oguz, R, Anak, S and Dorak, MT (2002) HLA-DRB1*15 and pediatric aplastic anemia. Haematologica, 87(7), pp. 772-774. ISSN (print) 0390-6078


We report a positive association between HLA-DRB1*15 (p= 0.0002) in Turkish patients with pediatric severe aplastic anemia (SAA) and a paradoxically favorable influence of the susceptibility marker on the clinical response to immunosuppressive therapy. These findings point to an immune mechanism mediated by DRB1*15 in SAA which confers responsiveness to treatment.

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