Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner.

Waheed, A., Ludtmann, M.H.R., Pakes, N., Robery, S., Kuspa, A., Dinh, C., Baines, D., Williams, R.S.B. and Carew, M. (2014) Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner. British Journal of Pharmacology, 171(10), pp. 2659-2670. ISSN (print) 0007-1188

Abstract

The action of naringenin on cell growth in the phylogenetically diverse systems of Dictyostelium and mammalian kidney cells, suggests a conserved effect mediated by polycystin-2 (TRPP2). Further studies will investigate naringenin as a potential new therapeutic agent in ADPKD.

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