Computer aided detection and measurement of coronary artery disease from computed tomography angiography images

Mazinani, Mahdi (2012) Computer aided detection and measurement of coronary artery disease from computed tomography angiography images. (PhD thesis), Kingston University, uk.bl.ethos.592759.

Abstract

Coronary artery disease is one of the most pernicious diseases around the world and early identification of vascular disease can help to reduce morbidity and mortality. Assessment of the degree of vascular obstruction, or stenosis, is critical for classifying the risks of the future vascular events. Automatic detection and quantification of stenosis are important in assessing coronary artery disease from medical imagery, especially for disease progression. Important factors affecting the reproducability and robustness of accuarate quantification arise from the partial volume effect and other noise sources. The main goal of this study is to present a fully automatic approach for detection and quantification of the stenosis in the coronary arteries. The proposed approach begins by building a 3D reconstruction of the coronary arterial system and then making accurate measurement of the vessel diameter from a robust estimate of the vessel cross-section. The proposed algorithm models the partial volume effect using a Markovian fuzzy clustering method in the process of accurate quantification of the degree of stenosis. To evaluate the accuracy and reproducibility of the measurement, the method was applied to a vascular phantom that was scanned using different protocols. The algorithm was applied to 20 CTA patient datasets containing a total of 85 stenoses, which were all successfully detected, with an average false positive rate of 0.7 per scan.

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