Dysfunctional mechanotransduction through the YAP/TAZ/Hippo pathway as a feature of chronic disease

Cobbaut, Mathias, Karagil, Simge, Bruno, Lucrezia, de Loza, Maria Del Carmen Diaz, Mackenzie, Francesca E, Stolinski, Michael and Elbediwy, Ahmed (2020) Dysfunctional mechanotransduction through the YAP/TAZ/Hippo pathway as a feature of chronic disease. Cells, 9(1), p. 151. ISSN (online) 2073-4409

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Abstract

In order to ascertain their external environment, cells and tissues have the capability to sense and process a variety of stresses, including stretching and compression forces. These mechanical forces, as experienced by cells and tissues, are then converted into biochemical signals within the cell, leading to a number of cellular mechanisms being activated, including proliferation, differentiation and migration. If the conversion of mechanical cues into biochemical signals is perturbed in any way, then this can be potentially implicated in chronic disease development and processes such as neurological disorders, cancer and obesity. This review will focus on how the interplay between mechanotransduction, cellular structure, metabolism and signalling cascades led by the Hippo-YAP/TAZ axis can lead to a number of chronic diseases and suggest how we can target various pathways in order to design therapeutic targets for these debilitating diseases and conditions.

Item Type: Article
Additional Information: This work was supported by the Francis Crick Institute.
Research Area: Biological sciences
Cancer studies
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing > School of Life Sciences, Pharmacy and Chemistry
Faculty of Science, Engineering and Computing
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Depositing User: Ahmed Elbediwy
Date Deposited: 10 Jul 2020 12:36
Last Modified: 10 Jul 2020 12:36
DOI: https://doi.org/10.3390/cells9010151
URI: http://eprints.kingston.ac.uk/id/eprint/46490

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