Whole genome sequence of 'Dermacoccus abyssi' MT1.1 isolated from the Challenger Deep of the Mariana Trench reveals phenazine biosynthesis locus and environmental adaptation factors

Abdel-Mageed, Wael M., Juhasz, Bertalan, Lehri, Burhan, Alqahtani, Ali S., Nouioui, Imen, Pech‐Puch, Dawrin, Tabudravu, Jioji N., Goodfellow, Michael, Rodriguez, Jaime, Jaspars, Marcel and Karlyshev, Andrey V. (2020) Whole genome sequence of 'Dermacoccus abyssi' MT1.1 isolated from the Challenger Deep of the Mariana Trench reveals phenazine biosynthesis locus and environmental adaptation factors. Marine Drugs, 18(3), p. 131. ISSN (print) 1660-3397

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Abstract

Dermacoccus abyssi strain MT1.1T is a piezotolerant actinobacterium that was isolated from Mariana Trench sediment collected at a depth of 10898 m. The organism was found to produce ten dermacozines (A‒J) that belonged to a new phenazine family and which displayed various biological activities such as radical scavenging and cytotoxicity. Here we report on the isolation and identification of a new dermacozine compound, dermacozine M, the chemical structure of which was determined using 1D and 2D-NMR, and high resolution MS. A whole genome sequence generated from the strain contained six biosynthetic gene clusters (BGCs), including one responsible for the biosynthesis of a family phenazine of compounds. The pathway leading to the biosynthesis of dermacozines is proposed. Bioinformatic analyses of key stress-related genes provide an insight into how the organism adapted to the environmental conditions that prevail in the deep-sea.

Item Type: Article
Additional Information: This work was supported by Researchers Supporting Project number (RSP‐2019/132), King Saud University, Riyadh, Saudi Arabia.
Research Area: Allied health professions and studies
Biological sciences
Epidemiology and public health
Infection and immunology
Faculty, School or Research Centre: Faculty of Science, Engineering and Computing
Faculty of Science, Engineering and Computing > School of Life Sciences, Pharmacy and Chemistry
Depositing User: Andrey Karlyshev
Date Deposited: 27 Feb 2020 11:27
Last Modified: 27 Feb 2020 11:27
DOI: doi.org/10.3390/md18030131
URI: http://eprints.kingston.ac.uk/id/eprint/45060

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